氟西汀对脑卒中后抑郁及神经功能康复的作用  

Effects of fluoxetine in nervous functional rehabilitations and post-apoplexy melancholia after apoplexy

作　　者：陈杭军[1] 余毅[1] 

机构地区：[1]广东省东莞市人民医院综合科,523018

出　　处：《医师进修杂志》2005年第7期24-25,28,共3页Journal of Postgraduates of Medicine

摘　　要：目的观察氟西汀对脑卒中后抑郁及神经功能康复的疗效。方法将73例早期(<2个月)脑卒中后抑郁患者随机分为氟西汀治疗组和对照组。两组病人均予脑卒中基础治疗,同时予简单的功能训练。治疗组加用氟西汀20mg,每日1次,对照组不使用任何抗抑郁药,疗程8周。观察病人在治疗前、治疗后4周、治疗后8周Hamilton抑郁量表评分(HDRS)、Zung抑郁自评量表评分(SDS)以及生活活动量表Barthel指数(BI)的变化情况。结果治疗组治疗后4周、8周HDRS、SDS以及BI评分与治疗前比较,差异有非常显著性(P<0.01);治疗组治疗后4周、8周HDRS、SDS及BI评分,与对照组比较差异有显著性(P<0.05)。同时氟西汀无明显毒副作用,患者耐受性好,服用安全。结论氟西汀可明显改善脑卒中后抑郁患者的抑郁症状,同时还能促进神经功能康复。Objective To observe the curative effects of fluoxetine on nervous functions and melancholia after apoplexy. Methods Seventy-three cases of post-apoplexy melancholia in the earlier period(less than 2 months) were randomly divided into two groups.The control group was only given the basic treatments of apoplexy.The treatment group was given fluoxetine 20 mg once a day in combination with the basic treatments of apoplexy at the same time for 8 weeks.The changes of HDRS、SDS、BI in two groups were observed. Result HDRS、SDS、BI after treated were more significantly improved (P<0.01) than those before treated in the treatment group,and more significantly improved (P<0.05) than those in the matched control group. Conclusion Fluoxetine can obviously improve the symptoms and nervous function of post-apoplexy melancholia.

关 键 词：神经功能康复 脑卒中后抑郁 氟西汀 HAMILTON 抑郁患者 量表评分 HDRS 治疗组 治疗后 对照组 基础治疗 功能训练 每日1次 抗抑郁药 变化情况 生活活动 抑郁自评 毒副作用 抑郁症状 治疗前 SDS 显著性 耐受性 病人 BI 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]