眼眶淋巴组织增生病的淋巴细胞免疫表型分析及其意义  

The immunophenotypic lymphocyte analysis of orbital lymphadenosis and its significance

作　　者：余英豪[1] 李军[1] 张佩伟[1] 骆荣江[2] 马群 

机构地区：[1]南京部队福州总医院 [2]第一军医大学附属珠江医院 [3]广州部队武汉总医院

出　　处：《中华眼科杂志》1994年第3期210-213,T021,共5页Chinese Journal of Ophthalmology

摘　　要：使用１０种单克隆抗体，以免疫组化染色Ｓ－Ｐ法对５６例眼眶淋巴组织增生病的石蜡标本进行淋巴细胞免疫表型标记。结果表明：炎性假瘤（１５／１５）及反应性淋巴组织增生（３２／３３）显示组成细胞的多克隆性；３例不典型淋巴组织增生中，２例为单克隆性，结合组织学改变可诊断为恶性淋巴瘤（ｍａｌｉｇｎａｎｔｌｙｍｐｈｏｍａ，ＭＬ）；５例ＭＬ均为单克隆性，经标记４例为Ｂ细胞，１例为Ｔ细胞来源。提示免疫组化染色方法有助于眼眶淋巴组织增生病良、恶性病变的鉴别诊断及ＭＬ的组织学分型。文中还就眼眶淋巴组织增生病的病理分类与免疫学分类的关系进行了探讨。Abstract An immunophenotypic lymphocyte analysis of 56cases of orbital lymphadenosis was performed with apanel of 10 monoclonal antibodies against thelymphocyte differentiation antigen by thestreptavidin-peroxidase conjugate method to revealthat(1)all 15 cases of inflammatory pseudotumor and32 of 33 cases of reactive lymphocyte hyperplasia man-ifested polyclonality of the constituent cells;(2)theimmunophenotype of cells was monoclonal in 2 of 3cases of atypical lymphocyte hyperplasia anddiagnosis of malignant lymphoma (ML)were estab-lished;and(3)among 5 cases of ML,the cells wereshown to be B-cells in4cases and T-cells in 1 case.These results suggested that immunophenotypingcould be useful in differentiating the benign from themalignant orbital lymphadenosis and the histologictypes of ML. The relationship between pathologic andimmunologic classifications of orbital lymphadenosiswas also discussed.

关 键 词：眼眶肿瘤 免疫测定 病理学 

分 类 号：R739.720.3[医药卫生—肿瘤]