超氧化物歧化酶及二乙基二硫氨基甲酸钠对诱发性大鼠肺鳞状细胞癌的作用  

EFFECT OF SUPEROXIDE DISMUTASE AND DIETHYLDITHIOCARBAMATE ON THE INDUCTION OF SQUAMOUS CELL CARCINOMA OF LUNG WITH METHYLCHOLANTHRENE IN RATS

作　　者：刘铭球[1] 喻伦银[1] 舒清波[1] 田鸿生[1] 夏东[1] 刁路明[1] 邹祖玉[1] 刘晓翌[1] 吴天鹏[1] 张龙记 

机构地区：[1]湖北医科大学病理学教研室

出　　处：《中华肿瘤杂志》1994年第4期269-272,T012,共5页Chinese Journal of Oncology

基　　金：国家自然科学基金

摘　　要：应用超氧化物歧化酶（ＳＯＤ）及其抑制剂二乙基二硫氨基甲酸钠（ＤＤＣ）分别给用甲基胆蒽（ＭＣＡ）碘油溶液诱发Ｗｉｓｔａｒ大鼠肺鳞状细胞癌的过程中用药。在３５、４０天诱癌中，发现ＤＤＣ组５０只大鼠３例发生肺鳞癌，４例支气管上皮呈不典型增生，ＳＯＤ组５２只未发生肺癌，１例发生不典型增生；对照组４２只１例发生肺鳞癌，２例不典型增生。肺癌发生情况ＤＤＣ组与ＳＯＤ组比较差别有显著性意义（Ｐ＜０．０５）。结果表明：ＤＤＣ与化学致癌物质ＭＣＡ诱癌有协同作用，使诱发性肺鳞癌提前发生。ＳＯＤ可能有抑制肺癌发生的作用。作者还对其作用机理进行了讨论。Abstract The squamous cell carcinoma of lung was induced with methylcholanthrene(MCA)in iodizedoil in Wistar rats. During the development of the cancer,the animals were given superoxidedismutase(SOD)or its inhibitor diethyldithiocarbamate (DDC).In DDC group,3 out of 50 rats de- veloped cancer and 4 developed atypical hyperplasia of bronchial epithelium within 35 to 40 days. In SOD group, no cancer developed in all of the 52 rats, and only one had atypical hyperplasiain the lungs.Only one of 42 control rats had cancer and 2 rats had atypical hyperplasia ofbronchial epithelium. The difference in cancer frequency between groups DDC and SOD wassignificant(P<0.05).The results suggest that there is a synergism between DDC and MAC in theinduction of lung cancer,while SOD can inhibit MCA- induced lung cancer development.Themechanism the effect of SOD and DDC was discussed.

关 键 词：肺肿瘤 鳞状细胞癌 甲基胆蒽 

分 类 号：R734.2[医药卫生—肿瘤]