经颅多普勒狭窄指数数理推导的合理性与应用中的若干问题  

Rationality of mathematico-physical inference of stenotic index on transcranial Doppler and some problems noticed in application

作　　者：吴钢[1] 陆兵勋[1] 许国英[2] 魏慧星[2] 郑依勇[2] 

机构地区：[1]南方医科大学南方医院神经内科,广州现在510515 [2]福建医科大学附属第一医院神经内科

出　　处：《中华神经科杂志》2005年第6期381-384,共4页Chinese Journal of Neurology

基　　金：福建省科技计划重点项目(2003Y038)

摘　　要：目的阐述经颅多普勒狭窄指数数理推导的合理性和应用中的若干问题。方法根据脑血流动力学原理,动脉狭窄指数(STI)的公式为:STI=1-(Vm0÷Vm1)×(Q1÷Q0),公式中的(Q1÷Q0)参数采用(PI1÷PI0)比值替代,推导出狭义狭窄指数公式和通用狭窄指数公式,我们对此过程进行数理逻辑推导,阐明公式的合理性;并与Lindegaard指数进行比较;阐述弹力系数的范围和意义以及弹力系数的选择注意点。结果血管狭窄时血流速度(Vm1)与狭窄血流的搏动指数(PI1)呈负相关,r=-0·65,P<0·01,n=55;Vm1与狭窄指数呈正相关,r=0·82,P<0·01,n=55;狭窄指数与Lindegaard指数呈正相关,r=0·82,P<0·01,n=55;从不同组弹力系数值的变化趋势,探讨狭窄指数通用公式弹力系数的选择,并推测弹力系数值的大小可能与动脉的弹性和管径大小有关。结论无论是狭义狭窄指数公式还是通用狭窄指数公式计算的STI,结果都可以较准确地表示动脉狭窄的百分比。Objective To elucidate the rationality of mathematico-physical in inference of stenotic index(STI) on transcranial Doppler(TCD) and some problems to be noticed in application. Methods Based on the principle of cerebral hemodynamics, the formula of arterial stenotic index (STI) is: STI=1-(Vm0÷Vm1)×(Q1÷Q0).The parameter of (Q1÷Q0) in the formula could not be obtained, so it is replaced with the ratio of (PI1÷PI0) by the author to infer out the restricted formula of stenotic index: STI=1-(Vm0÷Vm1)×(PI1÷PI0), and the current formula of stenotic index: STI=1- (PI1÷Vm1)×EM (EM is the elasticity modulus, EM=Vm0÷PI0 ). The process was mathematico-physical inferred in this paper, to elucidate the rationality of these formulas, and compare with Lindegaard index (LDGI) in the judgement of the stenotic degree of middle cerebral artery (MCA) during vascular spasm, introduced by Lindegaard et al in 1989, and to clarity the range and significance of EM as well as its noticed points in selection. Results The blood flow velocity during vascular stenosis (Vm1) is negatively correlated with the pulsation. Index of stenotic blood flow (PI1), r=-0.65,P<0.01, n=55; STI is positively correlated with LDGI, r= 0.82,P<0.01, n=55. Based on the tendency of variance of EM values is possibly related to the elasticity and diameter of the arteries. Conclusion The results of STI calculated by either restricted or current stenotic index formula could rather correctly represent the percentage of arterial stenosis, and have the greater stability.

关 键 词：经颅多普勒 若干问题 合理性 推导 数数 狭窄指数 动力学原理 数理逻辑 搏动指数 血流速度 血管狭窄 通用公式 动脉狭窄 正相关 力系 脑血流 注意点 负相关 STI 百分比 狭义 数值 

分 类 号：R445.1[医药卫生—影像医学与核医学]