Interaction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women  

作　　者：HongXU Ji-rongLONG Miao-xinLI 

机构地区：[1]LaboratoryofMolecularandStatisticalGenetics,CollegeofLifeSciences,Hu-nanNormalUniversity,Changsha410081,China//DepartmentofPhysiology,JiangxiMedicalCollege,Nanchang330006,China [2]OsteoporosisResearchCenterandDepartmentofBiomedicalSciences,CreightonUniversityMedicalCenter,601N30thSt,Suite6787,Omaha,NE68131,USA [3]LaboratoryofMolecularandStatisticalGenetics,CollegeofLifeSciences,Hu-nanNormalUniversity,Changsha410081,China

出　　处：《Acta Pharmacologica Sinica》2005年第7期860-864,共5页中国药理学报（英文版）

摘　　要：Aim:To evaluate whether estrogen receptor α(ER-α)and vitamin D receptor (VDR)genes are associated with the age at menarche in Chinese women.Methods: A total of 390 pre-menopausal Chinese women were genotyped at the ER-α PvuII, XbaI,and VDR Apal loci using polymerase chain reaction(PCR)-restriction frag- ment length polymorphism(RFLP).Results:Neither the ER-α gene nor the VDR gene individually had significant effects on the age at menarche in our subjects (P>0.10).However,evidence of interaction effects between the two genes were observed:with the aa genotype at the VDR ApaI locus,subjects with haplotype PX at the ER-α gene had,on average,6 months later onset of menarche than the non-carriers(P=0.01).Conclusion:We found that neither the ER-α gene or the VDR gene had a significant association with the age at menarche individually. However,potential interaction effects between the two genes were observed in Chinese women.Aim:To evaluate whether estrogen receptor α(ER-α)and vitamin D receptor (VDR)genes are associated with the age at menarche in Chinese women.Methods: A total of 390 pre-menopausal Chinese women were genotyped at the ER-α PvuII, XbaI,and VDR Apal loci using polymerase chain reaction(PCR)-restriction frag- ment length polymorphism(RFLP).Results:Neither the ER-α gene nor the VDR gene individually had significant effects on the age at menarche in our subjects (P>0.10).However,evidence of interaction effects between the two genes were observed:with the aa genotype at the VDR ApaI locus,subjects with haplotype PX at the ER-α gene had,on average,6 months later onset of menarche than the non-carriers(P=0.01).Conclusion:We found that neither the ER-α gene or the VDR gene had a significant association with the age at menarche individually. However,potential interaction effects between the two genes were observed in Chinese women.

关 键 词：MENARCHE ASSOCIATION HAPLOTYPE estrogen receptor a gene vitamin D receptor gene 

分 类 号：R711.51[医药卫生—妇产科学]