Carnoy液和三氯醋酸对金黄地鼠颊囊黏膜损伤作用观察  

Effects of Carnoy solution and trichloroacetic acid on the cheek pouch mucosa of hamster

作　　者：马民[1] 韩新光[2] 刘雅丽[1] 罗春霞[2] 

机构地区：[1]河南科技大学第一附属医院耳鼻咽喉科,洛阳471003 [2]郑州大学第一附属医院口腔科,郑州450052

出　　处：《郑州大学学报（医学版）》2005年第4期718-720,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:观察比较Carnoy液和不同浓度三氯醋酸(TCA)对颊囊黏膜组织的损伤特性。方法:20只金黄地鼠随机分为4组,每组5只。分别用Carnoy液、体积分数20%和35%的TCA、生理盐水处理各组金黄地鼠双侧颊囊黏膜,各组分别于处理后即刻、1周、3周、6周、12周处死动物1只,取颊囊黏膜组织,行HE染色、胶原纤维染色、酶组织化学染色,光镜及透射电镜观察形态学变化。结果与结论:各处理组颊囊黏膜均发生上皮坏死脱落,溃疡形成,坏死区上皮逐渐由新生上皮替代,并且出现纤维组织增生。Carnoy液处理组作用起效时间和作用强度均大于TCA处理组;35%TCA处理组作用强度大于20%TCA处理组。Aim: To observe the injury by Carnoy solution and trichloroacetic acid(TCA) on the cheek pouch mucosa of hamster. Methods: A total of 20 hamsters were allocated into 4 groups(5 in each group) and the pouch mucosa of the 4 groups were treated with Carnoy solution, 20% TCA, 35% TCA, and normal saline. The morphological change was observed under light and electron microscope. Results and Conclusion: Epithelial necrosis and ulcer formation were observed in the 4 groups.Cheek pouches were reepithialized and there was an apparent increase in the amount of collagen and fibroblast. Carnoy solution has longer and stronger effects than TCA;35% TCA has stronger effects than 20% TCA.

关 键 词：Carnoy液 三氯醋酸 金黄地鼠 颊囊 

分 类 号：R781.5[医药卫生—口腔医学]