玻璃体内注射曲安奈德治疗糖尿病性弥漫性黄斑水肿的初步观察  

Intravitreous injiection with triamcinolone acetonide for diffused diabetic macular edema

作　　者：姚毅[1] 王志军[1] 姜荔[1] 杨丙建[1] 王玮[1] 张卯年[1] 林顺潮[2] 

机构地区：[1]解放军总医院眼科,北京100853 [2]香港中文大学眼科及视觉科学系

出　　处：《中华眼底病杂志》2005年第4期217-219,共3页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的观察玻璃体内注射曲安奈德(TA)治疗糖尿病性弥漫性黄斑水肿的疗效。方法21例经眼底检查、荧光素眼底血管造影(FFA)和光相干断层扫描(OCT)检查确诊的糖尿病性弥漫性黄斑水肿患者接受玻璃体内注射40mg/ml的TA0.1ml治疗,随访1、3、6个月,对比观察治疗前后患眼视力、眼压以及黄斑区视网膜厚度的变化。视力用ETDRS视力表检查;眼压用非接触眼压计检查;视网膜厚度用OCT检查。结果注药后1个月时视力平均提高7.5个字母,OCT检查黄斑区视网膜厚度平均降低143μm,下降了33%。3个月时视力平均提高9.1个字母,10只眼提高2行以上,占48%,视网膜厚度平均降低184μm,下降了42%。6个月时视力平均提高5.1个字母,视网膜厚度降低了151μm,下降了35%。结论玻璃体内注射TA治疗糖尿病性弥漫性黄斑水肿短期内安全有效。Objective To observe the therapeutic effect of intravitreous injection with triamcinolone acetonide (TA) on diffused diabetic macular edema. [WTHZ]Methods Intravitreous injection with TA was performed on 21 patients with diabetic macular edema who had undergone ocular-fundus examination, fundus fluorescein angiography (FFA), and optical coherence tomography (OCT). The follow-up duration was 1 month, 3, and 6 months. The visual acuity, intraocular pressure, and retinal thickness at the macular area before and after the treatment, examined by ETDRS eye chart, non-contact tonometer, and OCT respectively, were observed and compared. Results One month, 3, and 6 months after the injection, the mean extent of improvement of visual acuity was 7.5, 9.1 (including 2-line improvement in 10 eyes which occupied 48%), and 5.1 letters respectively; while the decrease of retinal thickness at macula was 143 μm (decrease of 33%), 184 μm (decrease of 42%), and 151 μm (decrease of 35%) respectively. Conclusions Intravitreous injection with TA is effective for diffused diabetic macular edema in a short term (about 3 months).

关 键 词：黄斑水肿 囊样 药物疗法 曲安奈德 糖尿病 并发症 TA 玻璃体内注射法 

分 类 号：R774.5[医药卫生—眼科] R587.2[医药卫生—临床医学]