尼氟酸对大鼠体外心脏缺血-再灌注性心律失常及心功能的影响  

Effects of niflumic acid on ischemia-reperfusion arrhythmia and heart function in perfused rat hearts

作　　者：朱军[1] 王跃民[1] 马恒[1] 张鹏[1] 杨俊[1] 赖小刚[1] 周士胜[2] 

机构地区：[1]第四军医大学基础部生理学教研室,陕西西安710032 [2]大连大学医学院医学研究中心,辽宁大连116622

出　　处：《医学研究生学报》2005年第7期594-598,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金资助项目(批准号:30270602);军队杰出中青年人才基金资助项目(批准号:01J015)

摘　　要：目的:观察氯通道阻断药尼氟酸(NFA)对大鼠体外心脏缺血再灌注性心律失常及心功能的影响。方法:采用大鼠Langendorff体外心脏灌注模型,阻断冠状动脉,模拟心肌缺血,观察心功能指标、心率和心律失常积分值的变化。结果:NFA(10μmol/L)可使缺血性心律失常分数值明显降低(P<0.01),但对再灌注性心律失常无明显影响;NFA对体外大鼠心脏具有明显的负性变时和变力作用(P<0.05),且呈剂量依赖性。结论:氯通道阻断药NFA具有明显的抗缺血性心律失常作用。Objective: To investigate the effects of niflumic acid (NFA), a blocker of chloride channels, on ischemia-reperfusion arrhythmia and heart function in rats. Methods: The study was carried out in Langendorff perfused rat hearts subjected to coronary artery occlusion in which the severity of arrhythmias, index of heart function and heart rate were measured. Results: The severity of ischemia induced arrhythmia (arrhythmia score) was lower significantly in NFA(10mmol/L ) pertreated hearts than the control (P<0.01), but NFA had no effects on reperfusion-induced arrhythmia. In addition, NFA inhibited significantly the cardiac contraction and heart rates in a dose-dependent manner (P<0.05). Conclusion: The significant antiarrhythmic role of NFA, as a chloride channel blocker, was confirmed.

关 键 词：缺血-再灌注损伤 心律失常 氯通道 

分 类 号：R541.7[医药卫生—心血管疾病]