非小细胞性肺癌中P-gp表达与CD147、MMPs表达的关系  

Relationship Between the Expression of P-gp and that of CD147,MMPs in None Small Cell Lung Cancer

作　　者：董敏[1] 周仲文[1] 赵仲华[1] 张秀荣[1] 许祖德[1] 

机构地区：[1]复旦大学上海医学院病理学系,上海200032

出　　处：《复旦学报（医学版）》2005年第4期379-382,F002,共5页Fudan University Journal of Medical Sciences

基　　金：上海市卫生局科技发展基金资助(044082)

摘　　要：目的研究肿瘤细胞自然状态下耐药时,肿瘤细胞多药耐药与转移的关系。方法选取112例未经化疗的非小细胞性肺癌手术切除标本,用免疫组织化学染色观察P-gp、CD147、MMP-1、MT1-MMP的蛋白表达,分析各指标之间的关系。结果人肺癌组织中P-gp的表达与CD147、MMP-1、MT1-MMP具有明显的一致性,CD147、MMP-1、MT1-MMP在腺癌中表达高于鳞癌,且与淋巴结转移相关。结论非小细胞性肺癌自然状态下耐药时,P-gp与CD147、MMPs等肿瘤浸润、转移相关蛋白的表达之间可能存在着共同的调节机制。CD147对MMPs的调节,可能与多药耐药肿瘤的浸润、转移特性有关。Purpose To research the relationship between multidrug-resistance and metastasis of tumor cells in the clinical course. Methods P-gp,CD147,MMP-1 and MT1-MMP were tested by immunohistochemical method on the routinely paraffin-embedded sections of 112 cases with untreated none small cell lung cancer (NSCLC). Results In NSCLC the expression of P-gp,CD147,MMP-1,MT1-MMP was associa-ted each other.Compared with squamous carcinoma,adenocarcinoma overexpressed P-gp,CD147,MMP-1 and MT1-MMP more frequently.There was a significant correlation between increased CD147 expression and nodal metastasis,and was lack of evidence between sex,differentiation and TNM stages and target protein expression. Conclusions There would be a common regulation between increased expression of P-gp and CD147,MMPs in NSCLC. CD147 could stimulate the production of MMPs,which would be associated with invasion potentiality of multidrug-resistance tumor cells.

关 键 词：非小细胞性肺癌 CD147 P-GP表达 MMPS表达 MT1-MMP MMP-1 细胞多药耐药 手术切除标本 免疫组织化学 转移相关蛋白 自然状态 淋巴结转移 肿瘤细胞 染色观察 蛋白表达 肺癌组织 肿瘤浸润 调节机制 转移特性 一致性 

分 类 号：R734.2[医药卫生—肿瘤] R737.31[医药卫生—临床医学]