FCGR2A、FCGR3A基因多态性与Guillain-Barre综合征患者易感性的关联研究  

Analysis of the FCGR2A,FCGR3A gene polymorphisms in Guillain-Barre syndrome

作　　者：王雪婷[1] 代亚美[1] 盛利[1] 毕胜[1] 王德生[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院神经内科,黑龙江哈尔滨150001

出　　处：《中风与神经疾病杂志》2005年第3期216-218,共3页Journal of Apoplexy and Nervous Diseases

基　　金：黑龙江省博士后基金资助项目(LRB00097)

摘　　要：目的探讨FCGR2A[编码Fcγ受体(FcγR)a或FcγRIIa基因]、FCGR3A(编码FcγR a或FcγRIIIa基因)多态性与Guillain-Barre综合征(GBS)易感性的相关性。方法采用序列特异性引物多聚酶链反应(PCR-SSP),对64例GBS患者及69例健康对照者的FCGR2A-131和FCGR3A-158基因多态性进行检测,比较各组间等位基因型分布及等位基因频率的差异。结果经比较FCGR2A、FCGR3A的基因型分布、等位基因频率在GBS和正常对照中均无显著性差异(P>0.05)。结论FCGR2A-131、FCGR3A-158基因多态性与GBS易感性无相关性。Objective To investigate the polymorphisms of FCGR2A (gene coding Fcγ receptor Ⅱa or FcγRIIa),FCGR3A (gene coding Fcγ receptor Ⅲa or FcγRIIIa) and the association with the susceptibility of Guillian-Barre syndrome. Methods DNA of white blood cells from 64 subjects with GBS and 69 healthy controls was extracted. Polymorphisms in Fcγ receptor Ⅱa gene cluster and Fcγ receptor Ⅲa gene cluster were analyzed with PCR-SSP. The genotype distribution and allele frequency among different groups were compared. Results The genotype(HH,HR,RR)distribution of FCGR2A-131 was 9.4%,65.6%,and 25% in patients with Guillain-Barre syndrome and 18.8%,58.0% and 23.2% in controls (P>(0.05)). The allele frequency of FCGR2A-131 in patients with GBS were H131 42.2%,R131 57.8% and 47.8%;52.2% in controls (P>(0.05)). The genotype (VV,VF and FF) distribution of FCGR3A-158 were 10.9%,76.6% and 12.5% in patients with Guillain-Barre syndrome,and 13.0%,81.2% and 5.8% in controls (P>(0.05)). The allele frequency of FCRGR3A-158 in patients with GBS were V158 49.2%,F158 50.8% and 53.6%,46.4% in controls (P>(0.05)). Conclusion The polymorphisms of FCGR2A-131,FCGR3A-158 were not significantly associated with the susceptibility of Guilliain-Barre syndrome.

关 键 词：FCGR2A(Fcγ受体Ⅰ a基因) FCGR3A(Fcγ受体Ⅱa基因) Guillain—Barre综合征 基因多态性 

分 类 号：R745[医药卫生—神经病学与精神病学] Q346.5[医药卫生—临床医学]