巴曲酶对实验性糖尿病大鼠周围神经传导速度的影响  

The impact of Batroxobin on nerve conduction velocity of experimental diabetic peripheral neuropathy rats

作　　者：王宇石[1] 朱丹[2] 徐静[2] 饶明俐[2] 

机构地区：[1]吉林大学第一医院急救医学科,吉林长春130021 [2]吉林大学第一医院神经内科,吉林长春130021

出　　处：《中风与神经疾病杂志》2005年第3期241-242,共2页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨巴曲酶对糖尿病大鼠周围神经传导速度的作用。方法用链脲佐菌素一次性腹腔注射诱导糖尿病大鼠模型,在造模后2月和3月时腹腔注射巴曲酶8Bu/(kg·d),10d后测定坐骨神经运动及感觉神经传导速度。结果糖尿病大鼠在造模后2月和3月时周围神经传导速度明显减慢;用巴曲酶治疗的糖尿病大鼠周围神经传导速度明显加快。结论巴曲酶治疗能纠正糖尿病大鼠周围神经传导速度的异常。Objective To discuss the impact of Betroxobin on nerve conduction velocity of experimental diabetic peripheral neuropathy rats. Methods Diabetic rats were induced by a single intraperitoneal injection of streptozotocin. Results After 2 months and 3 months of diabetes,nerve conduction velocity was decreased significantly. After treatment with Batroxobin for 10 days,nerve conduction velocity was increased greatly. Conclusion Administration of Batroxobin can reverse abnormal nerve conduction velocity of experimental diabetic peripheral neuropathy rats.

关 键 词：糖尿病周围神经病 神经传导速度 巴曲酶 

分 类 号：R745[医药卫生—神经病学与精神病学]