电针对脑缺血再灌注损伤的治疗作用  

The Effect of Electroacupuncture on Cerebral Ischemia-reperfusion Injury

作　　者：陈世新[1] 李建雄[1] 侯健[1] 

机构地区：[1]咸宁学院生物医学工程系,湖北咸宁437100

出　　处：《咸宁学院学报（医学版）》2005年第3期155-157,共3页Journal of Xianning Univarsity(medical Sciences)

摘　　要：目的探讨电针对脑缺血再灌注损伤的治疗作用。方法用改良的血管内栓线技术制造大鼠局灶性脑缺血与再灌注模型,应用免疫组织化学技术检测脑组织中的nNOS阳性神经元的表达。电针穴位选择“水沟”“承浆”穴。结果①脑缺血再灌注组nNOS阳性神经元在大脑皮层和海马CA1区、CA3区大量表达,与正常对照组相同脑区比较有显著性差异(P<0.05);②电针能显著减少脑缺血再灌注损伤中nNOS阳性神经元在大脑皮层和海马CA1区、CA3区的表达,与缺血再灌注组相同脑区比较有显著性差异(P<0.05)。结论电针能显著减少脑缺血再灌注损伤中神经元的丢失。Objective To study the effect of electroacupuncture on cerebral ischemia-reperfusion(I-R) injury. Methods Modified intravascular embolism method was employed to make focal brain ischemia in rats.Immunohistochemical method was used to detect the expression of nNOS in brain.The acupuncture point of ‘Shui gou’and‘Chenjiang’ were adopted.Results ①Compared with the normal group,the expression of nNOS could be remarkably enhanced in the cortex of brain and the CA_1 and CA_3 of hippocampus after cerebral I-R( P <0.05). ②Compared with the I-R group, the expression of nNOS could be signifcantly reduced after electroacupuncture( P <0.05). Conclusion Electroacupuncture can decrease the lose of neurons in cerebral ischemia-reperfusion injury.

关 键 词：电针 缺血再灌注 一氧化氮合酶 大鼠 

分 类 号：R364.1[医药卫生—病理学]