组织端粒酶活性与宫颈癌相关研究  

Telomerase activity in uterine tissue and the advance of cervical cancer.

作　　者：卢亚祖[1] 李承彬[1] 欧阳耀灵[1] 范翠芳[2] 林静[2] 杨勇[3] 

机构地区：[1]湖北省荆州市中心医院检验医学部,434020 [2]湖北省荆州市中心医院妇产科,434020 [3]湖北省荆州市中心医院病理科,434020

出　　处：《中国优生与遗传杂志》2005年第7期34-35,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的为了了解宫颈组织端粒酶活性与宫颈癌的关系。方法在30例宫颈癌、72例宫颈CIN和16例正常宫颈新鲜组织中,端粒酶重复序列扩增法(TRAP)用于检测组织端酶活性。结果3组端粒酶活性阳性分别有22例,21例和1例(P<0·01),平均端粒酶活性分别为1·362±0·768、0·4236±0·247和0·048±0·026(P>0·01)。结论组织端粒酶活性的异常表达与宫颈癌进展密切相关,且随病程的进展端粒酶平均活性程度逐渐升高。Objective:To study the relationship between telomerase activity in uterine tissue.Methods:30 cases cervical cancer,72 cases cervical intraepithelial neoplasia and 16 cases normal control cervical fresh tissue were measured for telomerase activity using TRAP.Results:Telomerase activity was positive in 22 cases cervical cancer.21 cases CIN and 1case normal control(P<0.01).The average of telomerase activity are 1.362±0.768,0.436±0.274和0.048±0.026(P<0.01),respectively.Conclusion:The abnormal expression of telomerase activity is close associated with the advance of cervical cancer ,and the average of the telomerase activity was increased with the course of disease.

关 键 词：宫颈癌 端粒酶活性 TRAP 病程进展 

分 类 号：R737.33[医药卫生—肿瘤]