西酞普兰治疗儿童抑郁和情绪障碍临床研究  

Clinical studies of citalopram in children with depression and emotional disorder

作　　者：郭华[1] 杨长虹[1] 郭平[1] 

机构地区：[1]驻马店市精神病医院,河南驻马店463000

出　　处：《临床心身疾病杂志》2005年第3期213-214,共2页Journal of Clinical Psychosomatic Diseases

摘　　要：目的观察西酞普兰治疗儿童抑郁和情绪障碍的疗效及安全性。方法对23例儿童抑郁和情绪障碍患者给予西酞普兰治疗,初始剂量10mg·d-1,1w后视病情逐渐增加剂量,最高剂量≤50mg·d-1,平均剂量25±5.69mg·d-1,疗程8w。对存在严重失眠症状者酌情使用苯二氮艹卓类药物。于治疗前及治疗第4、8w末采用艾氏儿童行为量表评定临床疗效,副反应量表评定不良反应。艾氏儿童行为量表减分率≥60%为有效,<60%为无效。以艾氏儿童行为量表<5分为临床痊愈。结果治疗第4、8w末艾氏儿童行为量表评定总分、抑郁、焦虑、强迫因子分均较治疗前有显著下降,差异有极显著性(P均<0.01)。常见不良反应有体重增加,轻度胃肠道反应。结论西酞普兰治疗儿童抑郁和情绪障碍疗效显著,安全性高。Objective To explore the curative effects and safety of citalopram in children with depression and emotional disorder. Methods 23 children with depression and emotional disorder were treated with citalopram, initial dose was 10mg/d which gradually increased after one week, maximal ≤ 50mg/d and mean 25± 5.69mg/d for 8 weeks. The children who had severe insomnia were given benzodiazepines. Curative effects and adverse reactions were assessed with the Child Behavior Check-list(CBCL) and Treatment Emergent Symptom Scale(TESS) before treatment and at the ends of 4th and 8th week of treatment, respectively. The score-reducing rate of the CBCL ≥ 60% was effective and < 60% ineffective. The score of the CBCL < 5 was clinical recovery. Results Compared with pre-treatment, the total score and scores of depression, anxiety and compulsion significantly decreased at the ends of 4th and 8th week, difference was the most significant( all P<0.01). Main adverse reactions were weight gain and mild gastrointestinal reactions. Conclusion Citalopram has notable curative effect and high safety in children with depression and emotional disorder.

关 键 词：儿童 抑郁 情绪障碍 西酞普兰 

分 类 号：R749.4[医药卫生—神经病学与精神病学]