南瓜提取物对小鼠S-180移植性肿瘤的影响  

Effect of Pumpkin Extracts on Tumor Growth Inhibiton in S_(180)-bearing Mice

作　　者：潘洪志[1] 邱向红[1] 李辉[1] 金建文 于春林 赵景波[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院,黑龙江哈尔滨150001 [2]哈尔滨渴康生物工程制品有限公司

出　　处：《实用预防医学》2005年第4期745-747,共3页Practical Preventive Medicine

摘　　要：目的观察南瓜提取物的体内抗肿瘤作用。方法采用小鼠S180肉瘤建立荷瘤小鼠模型,给予南瓜提取物后观察荷瘤小鼠肿瘤生长情况及对小鼠免疫系统和抗氧化酶的影响。结果南瓜提取物具有明显的抗肿瘤作用,能够增强小鼠脾脏T淋巴细胞增殖能力,提高自然杀伤细胞(NK)活性,能够增强荷瘤小鼠腹腔巨噬细胞的吞噬功能,明显提高CD4+和CD8+T细胞的百分率及其比值,增强血清SOD、GSH-Px活性,降低MDA含量。结论南瓜提取物具有显著的抗肿瘤作用,其作用可能是通过增强免疫系统功能和抗氧化作用及降低脂质过氧化来实现的。Objective To observe the effect of pumpkin extracts(PKE) on tumor-bearing mice. Methods S_ 180 -bearing mice were used as animal model. The mice were administrated pumpkin extracts orally. The effects of PKE on tumor weight, immune function and antioxidative enzyme were examined. Results PKE markedly reduced tumor weight and promoted splenic lymphocyte proliferation, natural killer cell (NK) activity. PKE enhanced phagocytosis of macrophages in S_ 180 -bearing mice. PKE increased the number of CD4 + ,CD8 + and the CD4 +/CD8 + ratio, enhanced SOD , GSH-Px activities and reduced MDA level significantly(P<0.05). Conclusion Pumpkin extracts might inhibit the growth of S_ 180 tumor. The antitumor effect may be related to its immune effect and antioxidative effect and the reduction of lipid peroxidation.

关 键 词：南瓜提取物 肿瘤 S180 小鼠 

分 类 号：R73-3[医药卫生—肿瘤]