急性胰腺炎患者核因子-κB激活的检测  

The rapid detection of NF-κB activity in patiens with acute pancreatitis

作　　者：陈文亮[1] 王选[1] 韩曙光[1] 武世荣[1] 朱镭[1] 

机构地区：[1]山西医科大学第二医院普外科,山西省太原030001

出　　处：《中华急诊医学杂志》2005年第7期579-581,共3页Chinese Journal of Emergency Medicine

摘　　要：目的探讨核因子-κB激活在急性胰腺炎患者血液中的表达与时间关系.方法急性胰腺炎患者20例,对照组12例.采用流式细胞术检测外周血中核因子-κB激活.结果胰腺炎组各时段(＜24 h、24～48 h、48～72 h、＞72 h核因子-κB激活明显高于对照组,P＜0.05.24 h内核因子-κB明显激活(54.07±18.17)%;24～48 h达高峰(70.03±5.62)%,48 h以后逐渐减弱,一周后NF-κB激活向正常水平接近.对照组各时段核因子-κB激活不明显(P＞0.05).结论急性胰腺炎患者早期外周血中NF-κB 明显激活.可望应用NF-κB抑制剂抑制NF-κB激活,控制急性胰腺炎的进展.Objective To study the relationship between timing and degree of expression of nuclear factor-kappa B (NF-κB) activation in acute pancreatitis (AP) patients. Methods Between 2003 and 2004, 20 patients with AP were analyzed.Cytometry was used for detecting NF-κB activation in peripheral blood. Results NF-κB activation was significantly higher at each time point than that in control group (P<0.05). The NF-κB activity,(54.07±18.17)%,increased significantly at 24 hours,and peaked at 24 to 48 hours. NF-κB activity gradually decreased after 48 hous and was near to the normal level after one week. No significant difference was found at different time points in control group. Conclusion The activation of NF-κB in penpheral blood was significantly higher at early phrase in AP. NF-κB inhibitor could be considered to prevent the progression of AP.

关 键 词：核因子-ΚB 急性胰腺炎 患者 NF-ΚB激活 NF-ΚB抑制剂 流式细胞术检测 对照组 时间关系 0.05 外周血 72h 24h 时段 

分 类 号：R576[医药卫生—消化系统] R47[医药卫生—内科学]