周围型肺腺癌MRI动态增强参数与血管生成的相关性研究  

The Study of Relationship Between Dynamic Contrast-enhanced MRI Parameters and Angiogenesis in Peripheral Pulmonary Adenocarcinoma

作　　者：杨春山[1] 肖湘生[2] 刘士远[2] 周康荣[1] 李惠民[2] 李成洲[2] 

机构地区：[1]复旦大学医学院中山医院放射科 [2]第二军医大学长征医院放射科

出　　处：《临床放射学杂志》2005年第7期591-596,共6页Journal of Clinical Radiology

摘　　要：目的探讨周围型肺腺癌MRI动态增强参数与血管生成之间的相关性。资料与方法37例周围型肺腺癌患者行MRI动态增强扫描,用免疫组织化学测定微血管密度(MVD)并标定血管内皮生长因子(VEGF),评价MRI动态增强参数强化峰值(PH)、最大线性强化斜率(SS)、最大强化率(Emax)、增强后1～6min时的信号强化率(E1～6)与肺腺癌MVD的相关性,并比较VEGF表达阳性组与阴性组病例其MRI动态增强参数的差异。结果37例肺腺癌的MVD为68.31±19.84。MRI动态增强参数PH、SS、Emax、E1～6与肺腺癌的MVD呈正相关(P<0.001),其中以SS与MVD相关性最强(r=0.827,P<0.001)。26例VEGF表达阳性的肺腺癌MVD为79.47±21.35,11例VEGF表达阴性的肺腺癌其MVD为43.16±17.85,二者之间差异显著(P<0.001)。VEGF表达阳性的肺腺癌其MRI动态增强所有参数均明显高于VEGF表达阴性的肺腺癌(P<0.001)。结论肺腺癌MR动态增强参数与MVD呈正相关,VEGF表达阳性的肺腺癌其MR动态增强参数明显高于VEGF表达阴性的肺腺癌。Objective To investigate the relationship between dynamic contrast-enhanced MRI parameters and tumor angiogenesis in peripheral pulmonary adenocarcinoma.Materials and Methods 37 patients with pathologic proved pulmonary adenocarcinoma were underwent dynamic contrast-enhanced MR imaging, microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression were recorded with immunohistochemical method. Dynamic contrast-enhanced MRI-derived parameters Peak Height (PH), Steepest Slope (SS), Maximum Enhancement Rate (Emax), Enhancement Rate at 1～6 minutes (E_1～6) were calculated and compared with MVD in pulmonary adenocarcinoma. The dynamic contrast-enhanced MRI-derived parameters were compared between VEGF-positive and VEGF-negative pulmonary adenocarcinoma. Results The microvessel density was 68.31±19.84 in 37 pulmonary adenocarcinoma. The PH, SS, Emax, E_1～6 were correlated positively with MVD respectively (P<0.001). The highest strong relationship was found between SS and MVD (r=0.827, P<0.001). There was a significant difference between MVD of VEGF-positive pulmonary adenocarcinoma (79.47±21.35) and MVD of VEGF-negative pulmonary adenocarcinoma (43.16±17.85, P<0.001). Dynamic contrast-enhanced MRI-derived parameters in VEGF-positive pulmonary adenocarcinoma were higher than those in VEGF-negative pulmonary adenocarcinoma (P<0.001).Conclusion Dynamic contrast-enhanced MRI-derived parameters of pulmonary adenocarcinoma are correlated positively with MVD. Dynamic contrast-enhanced MRI-derived parameters in VEGF-positive pulmonary adenocarcinoma were higher than those in VEGF-negative pulmonary adenocarcinoma (P<0.001).

关 键 词：周围型肺腺癌 MRI动态增强参数 血管生成 血管内皮生长因子 微血管密度 

分 类 号：R734.2[医药卫生—肿瘤] R445.2[医药卫生—临床医学]