P53和NM23/NDPK在非小细胞肺癌中表达的意义  

Relationship between Expression of P53 and NM23/NDPK in Non-Small-Cell Lung Cancer

作　　者：纪远中[1] 聂卫[1] 张志尧[2] 戈以椿[2] 匡朴[1] 李德华[1] 王士贤[1] 

机构地区：[1]天津市医药科学研究所,300020 [2]天津市胸科医院

出　　处：《天津医药》2005年第7期411-413,i001,共4页Tianjin Medical Journal

基　　金：天津市卫生局科技基金资助项目(项目编号:96KY-GG18)

摘　　要：目的:探讨非小细胞肺癌(NSCLC)中P53与NM23/NDPK表达的相关性及其临床意义。方法:采用S-P免疫组化染色技术,检测69例NSCLC中P53及NM23/NDPK的表达情况。结果:P53及NM23/NDPK的表达与患者的生存率有关(P<0.05),P53与NM23/NDPK的表达和肺癌淋巴结转移密切相关(P<0.01)。结论:P53和NM23/NDPK的表达在NSCLC淋巴结转移中起协同作用。联合检测NSCL中P53及NM23/NDPK的表达对于判断预后和指导治疗具有一定的临床价值。Objective This study was designed to investigate the expression of P53 and NM23/NDPK in non-small-cell lung cancer NSCLC. Methods The expression of P53 and NM23/NDPK were detected by S-P immunohistochemical methods in 69 NSCLC patients. Results P53 and NM23/NDPK expressions were correlated with lymph node metastasis in NSCLCP < 0.01. The survival rate in patients was correlated P53 and NM23/NDPK expressions P < 0.05. Conclusion Combined detection of expression of P53 and NM23/NDPK in NSCLC may have practical value in prognosis of the NSCLC patients.

关 键 词：NM23/NDPK P53 非小细胞肺癌(NSCLC) 免疫组化染色技术 淋巴结转移 临床意义 表达情况 协同作用 临床价值 指导治疗 判断预后 联合检测 相关性 S-P 生存率 

分 类 号：R734.2[医药卫生—肿瘤] R735.2[医药卫生—临床医学]