U251胶质瘤细胞侵袭性原子力显微镜研究  

Atomic force microscope study of invasion ability of U251 glioma cells

作　　者：郁毅刚[1] 徐如祥[1] 丁涟沭[1] 柯以铨[1] 蔡颖谦[1] 

机构地区：[1]南方医科大学珠江医院神经外科,广州510282

出　　处：《中华神经医学杂志》2005年第7期658-660,共3页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(30170961);军队十五重点科研基金(01Z054)

摘　　要：目的探讨胶质瘤表面特化结构对其侵袭性的影响。方法应用原子力显微镜,对U251胶质瘤细胞系进行观测。结果胶质瘤细胞表面有大量伪足结构和微绒毛结构。结论原子力显微镜是研究亚细胞超微结构的有力武器。胶质瘤的微绒毛和伪足结构与其侵袭性相关。Objective To discuss the influence of the specialized s tructure on the surface of glioma cells on the invasive ability. Methods T he cultured U251 glioma cell line was detected with atomic force microscope(AFM) . Results There are many pseudopodia and microvilli on the glioma cell sur face. Conclusion AFM is an excellent instrument for observe the subcellula r ultrastructure. The pseudopodia and microvilli on the glioma cell surface are associated with the invasive ability of the glioma cells.

关 键 词：神经胶质瘤 伪足 微绒毛 侵袭 显微镜检查 原子力 

分 类 号：R739.4[医药卫生—肿瘤]