异喹啉生物碱类化合物的合成及其血管紧张素Ⅱ受体拮抗活性  

The synthesis of isoquinoline alkaloids and their inhibitory activity against angiotensin Ⅱ

作　　者：陈治宇[1] 刘丽艳[1] 王宏伟[1] 

机构地区：[1]承德医学院化学教研室,河北承德067000

出　　处：《化学试剂》2005年第7期422-424,446,共4页Chemical Reagents

基　　金：河北省自然科学基金项目(202583)

摘　　要：合成了14个未知的异喹啉衍生物,其化学结构经红外光谱、核磁共振氢谱、核磁共振碳谱、质谱及元素分析等证实。经大鼠肝细胞膜血管紧张素Ⅱ受体拮抗活性研究表明,其中两个化合物的盐酸盐具有生物活性。Fourteen isoquinoline compounds were synthesized and none of them has been reported before.Their structures were (identified) by elemental analysis,IR,MS,(~1HNMR) and (^(13)CNMR) spectra.Two of them showed inhibitory activity against angiotensin Ⅱ.

关 键 词：合成 异喹啉 生物碱 

分 类 号：R914[医药卫生—药物化学]