2－托品酮全合成方法改进  

IMPROVED TOTAL SYNTHESIS OF 2-TROPANONE

作　　者：王林[1] 恽榴红[1] 张其楷[1] 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《中国医药工业杂志》1995年第12期551-553,共3页Chinese Journal of Pharmaceuticals

摘　　要：以环庚三烯为原料，经氰化、环加成、水解和重排降解，全合成２－托品酮，总收率４０％。本法步骤短、操作简便、收率高。Tropanone was totally synthesized from cycloheptatriene in five steps. 2-Cyano-2-tropene was prepared by reaction of 7-cyano-1,3,5-cycloheptatriene with 25% of methylamine solution in alcohol. By partially acidic hydrolysis, it was directly converted into 2-carbamido-2-tropene, which was degraded with a fresh prepared basic sodium hypochlorite solution via Hofmann rearrangement to give 2-tropanone. The overall yield was 40%.

关 键 词：托品酮 合成工艺 制药 庚三烯 

分 类 号：TQ463.24[化学工程—制药化工]