Syntheses of Nucleoside Derivatives Containing Fmocor Trityl-protected Amino Acids  

作　　者：GUOHui ZOUWu-xin JIQi MAYu-xin MENGJi-ben 

机构地区：[1]DepartmentofChemistry,NankaiUniversity,Tianjin300071,P.R.China

出　　处：《Chemical Research in Chinese Universities》2005年第4期447-451,共5页高等学校化学研究（英文版）

基　　金：SupportedbytheNationalNaturalScienceFoundationofChina(Nos.20072018and20372039).

摘　　要：Facile direct esterification reactions between 2′,3′-O-isopropylidene-nucleosides and Fmoc- or trityl-protected amino acids %via% N,N-dicyclohexyl-carbodiimide(DCC) mediated condensation are described. These reactions offer a mild and convenient method to synthesize aminoacylated nucleoside derivatives.Facile direct esterification reactions between 2′,3′-O-isopropylidene-nucleosides and Fmoc- or trityl-protected amino acids %via% N,N-dicyclohexyl-carbodiimide(DCC) mediated condensation are described. These reactions offer a mild and convenient method to synthesize aminoacylated nucleoside derivatives.

关 键 词：NUCLEOSIDE Amino acid ESTERIFICATION 2′ 3′-O-Isopropylidene-nucleoside 

分 类 号：O626.413[理学—有机化学] O629.74[理学—化学]