脑源性神经营养因子基因C270T多态性与精神分裂症的关联研究  

An association study of schizophrenia and the C270T polymorphism of brain-derived neurotrophic factor gene

作　　者：何小林 [1] 赵靖平 [2] 刘铁桥 [2] 刘涛 [2] 张向晖 [2] 

机构地区：[1]广州市脑科医院定向博士生 [2]410011,长沙,中南大学精神卫生研究所

出　　处：《中国行为医学科学》2005年第7期623-624,共2页Chinese Journal of Behavioral Medical Science

基　　金：国家自然科学基金资助项目(30470622/C030308)

摘　　要：目的研究脑源性神经营养因子(BDNF)基因C270T多态性与精神分裂症的相关性。方法运用聚合酶链反应技术检测194例精神分裂症和187例正常对照的BDNF基因C270T多态性的分布频率。结果精神分裂症的C/T和T/T基因型的分布频率分别为26.8%和14.4%;而对照组分别5.9%和2.7%,两组差异有显著性(P<0.05)。基因型为C/C或C/T患者在阴阳性症状量表阳性症状量表分,阴性症状量表分和一般精神病理分方面没有统计学意义。结论BDNF基因C270T多态性与精神分裂症相关。ObjectiveTo explore the association between schizophrenia and C270T polymorphism of BDNF gene. MethodsPCR technique was applied to investigate a novel polymorphism of single nucleotide substitution (C270T) of the brain-derived neurotrophic factor (BDNF)gene in schizophrenia( n =194)and in normal controls( n =187). ResultsThe frequency of the C/T genotype and T allele were significantly high in schizophrenic patients(26.8%,14.4% respectively) compared with the controls(5.9%,2.7% respectively ).There were no significant difference in positive and negative symptom scale (PANSS)items as well as PANSS-G between the patients with C/C and C/T genotype. ConclusionThe C270T polymorphism of the brain-derived neurotrophic factor gene was associated with schizophrenia.

关 键 词：脑源性神经营养因子 精神分裂症 多态性 关联研究 BDNF基因 阳性症状量表 聚合酶链反应 阴性症状量表 分布频率 正常对照 技术检测 精神病理 基因型 相关性 显著性 统计学 

分 类 号：R749.3[医药卫生—神经病学与精神病学]