血宝胶囊抗放化疗损伤的实验研究  

Experimental study on xue-bao capsules against injury of radiation or cyclophosphamide in mice

作　　者：高天红 朴晋华 张丽 张蕻 

机构地区：[1]山西省药品检验所药理室,山西太原030001

出　　处：《中国中药杂志》2005年第14期1102-1105,共4页China Journal of Chinese Materia Medica

摘　　要：目的:通过复制放、化疗损伤的动物模型,观察血宝胶囊抗放化疗损伤、抗贫血效应,为其临床应用提供实验依据。方法:分别采用辐射损伤法、化学损伤法造成小鼠血虚模型,计数其对外周血白细胞、红细胞、血红蛋白、血小板和骨髓液红系祖细胞和粒系祖细胞的影响。结果:血宝胶囊对正常小鼠的骨髓红系祖细胞和粒系祖细胞增殖有促进作用;对小鼠60Coγ射线3.5 Gy照射所致的外周白细胞、红细胞及血红蛋白的降低具有保护作用,并对60co辐射所致红系祖细胞和粒系祖细胞增殖的降低有明显的恢复作用;具有抗环磷酰胺引起的小鼠白细胞、红细胞及血小板降低作用。结论:血宝胶囊具有抗放化疗损伤、抗贫血作用。Objective: To explore the effects of xue-bao capsules on injury of radio-or chemo-therapy in mice,in order to provide rationale behind clinical trials. Method: xue-xu (deficiency of blood) model in mice was induced by radiation or cyclophosphamide. Leucocyte (WBC), erythrocyte(RBC), hemoglobin(Hb) and pletelet(Pt) in peripheral blood as well as CFU-E and CFU-Gm in bone marrow were counted. Result: CFU-E and CFU-Gm in normal mice were promoted by this drug. The reduction of WBC,RBC and Hb in peripheral blood as well as CFU-E and CFU-Gm in bone marrow owing to the 3.5 Gy of 60Co radiation were antagonized by the durg. It had also antagonized cyclophosphamide induced the reduction of WBC, RBC and R in peripheral blood. Conclusion: xue-bao capsules has the effects against the adverse reactions of radio-or-chemo-therapy.

关 键 词：血宝胶囊 再生障碍性贫血 ^60Coγ射线 环磷酰胺 

分 类 号：R73-36[医药卫生—肿瘤]