肝炎后肝硬化患者血浆uPA与血清HA、IVC、LN的相关性研究  

The relationship of plasm urokinase plasminogen axtivatouon( uPA) and Serum Ayaluronic acid (HA), Ⅳ Collagen, Laminin( LN) in Posthepatitic Cirrhosis Patients

作　　者：钱佳平[1] 

机构地区：[1]浙江省湖州市中心医院感染内科,313000

出　　处：《浙江临床医学》2005年第7期678-679,共2页Zhejiang Clinical Medical Journal

摘　　要：目的探讨血浆尿激酶型纤溶酶原激活物(uPA)与血清肝纤维化指标透明质酸(HA)、Ⅳ型胶原(IVC)及层粘连蛋白(LN)在肝硬化发展中的临床意义及相关关系。方法对92例肝硬化患者采用Child pugh方法进行肝功能分级并进行分组。A组30例(A级)、B组32例(B级)、C组30例(C级)。30名健康者作健康对照组。ELISA法测定uPA、PAI-1,并同时测定HA、IVC、LN。结果随着肝硬化进展, 不同Child pugh分级肝硬化患者血清uPA、PAI-1、PAI-1/uPA均升高,HA、IVC、LN也逐步升高。uPA、PAI-1与LN无明显相关;uPA与HA、IVC无明显相关;而PAI-1与HA、IVC正相关。r分别为0.618、0.523,P均<0.01。结论随着肝硬化进展,ECM降解指标uPA相对不足和合成增加指标HA、IVC、LN持续升高,ECM合成超过降解。uPA、PAI-1与肝硬化发展有密切关系。Objective To investigate the clinical significance and relationship of plasm urokinase plasminogen axtivatouon(uPA) and hyaluronie acid (HA), Ⅳ Ⅳcollagen( IVC) and laminin(LN) in the development of liver cirrhosis. Methods 92 cases were divided into experiment groups according to Child pugh, which 30 cases in A group(A grade) ,32 cases in B group(B grade) and 30 cases in C group(C grade). Meanwhile 30 healthy cases in control group. The lever of uPA, PA1 - 1, HA, IVC and LN were measured in all cases with ELBA. Results The level of uPA, PAI - K PAI - 1 /uPA, HA IVC, LN for all cases in experiment groups were increased with the development of liver cirrhosis. There was no correlation between uPA,PAI - 1 and LN, between uPA and HA , IVC On the contrary , the PAI - 1 lever was positively correlated with HA and IVC respectively ( r = 0.618, P <0.01; r = 0.523, P < 0.01). Conclusion The lever of uPA ( degradation marker of extracellular matrix, ECM) was relative deficiency and the level of HA JVC,LN (synthesis marker of ECM) was gradually increased with the development of liver cirrhosis. There were intimate relationship between the lever of uPA, PAI - 1 and the degree of liver cirrhosis.

关 键 词：肝炎后肝硬化 尿激酶型纤溶酶原激活物 透明质酸 Ⅳ型胶原 层粘连蛋白 

分 类 号：R575.2[医药卫生—消化系统]