Neuroprotective effects of prostaglandin A1 and its effect on IKK／IkB／NF-kB／c-myc signaling pathway in rat models of permanent focal cerebral ischemia  

作　　者：Hui-lingZHANG Zhen-lunGU Zheng-hongQIN 

机构地区：[1]DepartmentofPharmacology,SoochowUniversitySchoolofMedicine,Suzhou215007

出　　处：《中国药理通讯》2005年第2期24-25,共2页

摘　　要：AIM Prostaglandin A1(PGA1) is a cyclopentenone prostaglandin. Recently, we reported that PGA1 can inhibit excitotoxin-induced apoptosis of striatal neurons in vivo and rotenone-induced apoptosis ofcultured SH-SY5Y cells, suggesting that PGA1 may have neuroprotective efficacy, possibly mediated by inhibition of NF-kB activation. The present study evaluated the neuroprotective potential of PGA1 and its effect on IKK/I( B/NF-kB/c-myc signaling pathway in rat models of permanent focal cerebral ischemia. METHODS Permanent middle cerebral artery occlusion (pMCAO) model was constructed by intraluminal suture cannulation through the internal carotid artery in Wistar rats.

关 键 词：神经原纤维 PGA1 前列腺素A1 IKK/IkB/NF-kB/c-myc 信号路径 老鼠 大脑疾病 

分 类 号：R742[医药卫生—神经病学与精神病学]