59例急性白血病患者雌激素受体的检测  

Detection of estrogen receptor in 59 acute leukemia patients

作　　者：李薇[1] 谢兆霞[2] 谭达人[2] 肖佩玲[1] 张国元[3] 

机构地区：[1]湖南省人民医院血液科,湖南长沙410002 [2]中南大学湘雅医院血液科,湖南长沙410008 [3]中南大学湘雅医院儿科,湖南长沙410008

出　　处：《中国现代医学杂志》2005年第12期1860-1861,1864,共3页China Journal of Modern Medicine

摘　　要：目的探讨急性白血病细胞雌激素受体(ER)表达及其对急性白血病预后的意义。方法采用免疫组化ABC法检测了59例急性白血病患者及20例对照组骨髓单个核细胞的ER表达。结果AL初诊组(13.83±9.39%)与完全缓解组(12.71±7.09%)ER+细胞率明显高于对照组(6.25±3.78%)(P<0.05),而难治复发组ER+细胞率(5.93±2.52%)明显低于完全缓解组和初诊组(P<0.05)。对照组男性与女性、AL组男性与女性、对照组≤50岁患者与>50岁患者、AL组≤50岁患者与>50岁患者、ANLL组与ALL组ER+率比较均无统计学意义(P>0.05)。结论ER表达与性别、年龄、AL类型无关。白血病细胞ER检测对疗效判断具有一定意义。[Objective] To evaluate the expression of estrogen receptor in acute leukemia patients and the prognosis significance to the acute leukemia. [Method] The ER expression in mononuclear cells of bone marrow was measured in 59 patients with AL and 20 control subjects by immunohistochemical technique. [Result] Both the untreated group(13.83±9.39%)and the complete remission group (12.71±7.09%) had higher positive cell rates of ER than in the control group (6.25±3.78%)(P <0.05), while the ER expression was lower in the relapsed-refractory group(5.93±2.52%) than the complete remission group and the untreated group respectively(P <0.05). The ER+ ratios between males and females in control subjects, males and females in AL group, ≤50 years old patients and >50 years old patients in control subjects, ≤50 years old patients and >50 years old patients in AL group, the ANLL group and the ALL group were no difference respectively(P >0.05). [Conclusion] The ER expression is not correlated with sex, age and the type of AL. Detection of ER helps to predict clinical and prognosis to some certain.

关 键 词：急性白血病 雌激素受体 

分 类 号：R733.71[医药卫生—肿瘤]