^(99)Tc^m-HL91 SPECT肺癌显像研究  

Clinical Research on Lung Cancer Imaging with ^(99)Tc^m-HL91 SPECT

作　　者：李玲[1] 邢力刚[1] 于金明[1] 徐瑾[1] 李国梁[2] 方永存[2] 

机构地区：[1]山东省肿瘤医院放疗二科,山东济南250117 [2]山东省肿瘤医院核医学科,山东济南250117

出　　处：《实用放射学杂志》2005年第7期757-759,共3页Journal of Practical Radiology

基　　金：山东省科技厅重大项目基金资助(021130103)

摘　　要：目的研究99Tcm-HL91SPECT肺癌显像与病理类型及病灶大小的关系。方法经病理证实的非小细胞肺癌患者共30例,利用SPECT仪采集注射740MBq99Tcm-HL91后2h、4h及6h的前位、后位及侧位平面图像,利用感兴趣区(ROI)技术分别勾画各时相肿瘤(T)和对侧相应部位(N)ROI,计算T/N比值。患者于HL91SPECT检查1周内行CT检查,测量CT图像上病灶大小。结果HL91选择性地浓集于肿瘤组织,浓集区域与CT显示肿瘤区域一致。显像清晰,以4h效果为最佳,2h、4h和6hT/N比值有统计学差异(P=0.041)。鳞癌组及腺癌组4hT/N差异无显著性(P=0.365),病灶大小与T/N无相关关系(Ρ=0.702)。结论99Tcm-HL91显像是一项有价值的肺癌检查手段,而与病理类型及病灶大小无相关性。Objective To evaluate the relationship between pathologic type and tumor size of non-small cell lung carcinoma(NSCLC) with 99Tcm-HL91 SPECT imaging. Methods 30 patients with pathologically proved NSCLC were undergone chest planar static imaging using a GCA-901A/HG SPECT system after 2 h,4 h and 6 h administration of 740MBq 99Tcm-HL91 . Regions of interests (ROIs) were drawn in the tumor and contralateral position and the radioactivity ratios of tumor to normal (T/N) were calculated . The relations between T/N value and the results of CT and pathology were analyzed . Results 99Tcm -HL91 SPECT imaging showed local uptake in thoracic lesions just identical with CT images , and images at 4 h were the best . There was statistical difference of T/N value at 2 h , 4 h and 6 h (P=0.041). There was no statistical difference between squamous cell carcinoma cases and adenocarcinoma cases (P=0.365). There was no correlation between tumor size and T/N value (P=0.702).Conclusion 99Tcm -HL91 imaging is a valuable diagnostic method for lung cancer, however, it has no relevance to pathologic type and tumor size.

关 键 词：肺癌 99^Tc^m-HL91 放射性核素显像 

分 类 号：R734.2[医药卫生—肿瘤]