胃尔康治疗慢性萎缩性胃炎的临床及实验研究  

Clinical and Experimental Study on Gastrosia Convalescens in Treating Chronic Atrophic Gastritis

作　　者：李春越[1] 施新猷[1] 周绍娟 张经济 任登先 桂郁富 巴善铎 孙桂华 李兴培[1] 孙起文[1] 

机构地区：[1]兰州军区乌鲁木齐总医院,第四军医大学实验动物研究中心,兰州医学院生理教研室,新疆医学院附属医院,新疆维吾尔自治区医院,广州军区广州总医院

出　　处：《中国中西医结合杂志》1995年第1期21-24,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：本研究临床观察了胃尔康片对慢性萎缩性胃炎（ＣＡＧ）脾胃阴虚证的疗效。采用单盲法，对照药为维酶素。两组服药前后作纤维胃镜及病理活检。结果：治疗组３２３例中临床治愈１１８例（３６．５３％），显效１３５例（４１．７９％），有效６１例（１８．８９％），无效９例（２．７９％）；总有效率９７．２１％。对照组１０５例中显效８例（７．６２％），有效３５例（３３．３３％），无效６２例（５９．０５％）；总有效率４０．９５％。两组比较差异有显著性意义（ｘ２＝１６６．６，Ｐ＜０．０１）。病理检查显示肠上皮化生及不典型增生消失率治疗组均优于对照组（ｐ＜０．０１）。实验研究采用Ｗｉｓｔａｒ大鼠作ＣＡＧ模型及胃尔康的长期毒性试验，应用狗作胃尔康对胃肠电活动影响的试验。结果：胃尔康长期毒性试验表明，高剂量（１０ｇ／ｋｇ）组有轻度兴奋反应，中（５ｇ／ｋｇ）、低（１ｇ／ｋｇ）剂量组无毒副反应。动物ＣＡＧ模型试验表明，胃尔康有显著的消炎、强壮、健脾作用外，还有促进萎缩腺体再生和修复之功效。对狗胃肠电活动影响，主要起兴奋作用，优于吗丁啉（Ｐ＜０．０５）。Gastrosia convalescens(GC)is a new drug for treating the Spleen-Yin Deficiency syndrome of chronic atrophic gastritis(CAG).Animal experiment has shown that GC has the function of promoting the regeneration of atrophic glands,and that of anti-inflammation, reinforcing,strengthening the stomach etc.It has the effect on the intestinal electric activity in dogs,mainly exciting in action,which was superior than that of domperidoni(P<0.05).The result of clinical study has demonstrsted that the marked effective rate of GC was 78.32%,CAG reversed into chronic superficial gastritis(CSG) in 30.0% of patients(60/200 cases),CAG into chronic superficial atrophic gastritis(CSAC)in 39.0%(78/200 cases).and CSAG into CSG in 39.02%(48/123 cases).The disappearance rate of metaplasia of intestinal epithelium and atypical hyperplasia were 39.1% and 38.14% respectively.There was a very significant difference in comparing with control group(P<0.01).

关 键 词：胃尔康片 脾胃阴虚证 萎缩性胃炎 胃炎 

分 类 号：R573.32[医药卫生—消化系统]