中药调神口服液治疗儿童多动症临床与实验研究  

Clinical and Experimental Studies on Tiaoshen Liquor for Infantile Hyperkinetic Syndrome

作　　者：王立华[1] 李成韶[1] 李国忠[1] 张亚荣[1] 邢向辉[1] 

机构地区：[1]山东中医学院,山东中医药研究所,山东中医学院实验药厂

出　　处：《中国中西医结合杂志》1995年第6期337-340,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：用中药调神口服液治疗儿童多动症１００例，治疗后行为评分明显降低，注意力涣散好转，学习成绩提高，总有效率达９４％。动物实验结果表明：该药有使正常小鼠自发活动减少的趋势，可显著减少东莨菪碱多动模型小鼠的自发活动；增强正常小鼠的学习记忆功能；对东莨菪碱、亚硝酸钠、乙醇三种记忆障碍模型小鼠的学习记忆功能均有不同程度改善，从而提示该药治疗本病的机理，可能与改善中枢神经系统胆碱能神经突触的信息传递功能，提高脑组织的耐缺氧能力有关。One hundred children with hyperkinetic syndrome were treated by using Tiaoshen Liquor(TL)consisted of Chinese herbal drugs.After the treatment,the behavior grading lowered greatly,their attention was improved,and their academic records raised.The total effective rate reached 94%.The results of the animal experiments showed that TL could reduce the spontaneous activities of the healthy mice,thus lowering remarkably the spontaneous activities in the mice with hyperkinetic behavior caused by taking scopolamine;reinforce the learning memory in the healthy mice;and improve in different degrees the learning memory of the mice with dysmnesia caused by administering scopolamine,sodium nitrite and alcohol respectively,which indicate that the therapeutic mechanism of TL for this syndrome was probably related to the improvement of information transfer function of the cholinergic neuron synapses of central nervous system and to the enhancement of hypoxia tolerence of the cerebral tissues.

关 键 词：调神口服液 儿童多动症 动物实验 

分 类 号：R749.940.5[医药卫生—神经病学与精神病学]