Snail与肿瘤  

Snail and Tumor

作　　者：张儒英[1] 乔惠珍[1] 

机构地区：[1]内蒙古医学院附属医院妇产科,内蒙古呼和浩特010050

出　　处：《内蒙古医学杂志》2005年第7期614-616,共3页Inner Mongolia Medical Journal

摘　　要：目的:对Snail的结构、功能、与E—钙粘附素的相关性,以及与肿瘤发生、转移的关系和可能作用机制作一综述。方法:收集、查阅大量国内外有关的文献。结果与结论:Snail是一个锌指转录因子,在胚胎发生、细胞分化及肿瘤的侵袭和转移中,均抑制E-钙粘附素的表达,因此,Snail与肿瘤的发生、演进关系密切。Objective:To sum up the structure,function,correlations with E-cadherin,tumorigenesis and metastasis,and their possible mechanism.Methods:Consulting related literatures home and aboard.Results and conclusion:Snail is a zinc finger transcription factor.It suppresses the expression of E-cadherin in embryogenesis,invasion and metatasis of tumors.As a result,snail is closely related to genesis and development of tumors.

关 键 词：SNAIL E-钙粘附素 肿瘤 

分 类 号：R737.33[医药卫生—肿瘤]