联合中药治法抑制大鼠肝癌的实验研究  

An Experimental Study on United Herbsinhibiting Hepatocarcinoma Rats Induced by 2-AAF

作　　者：施公胜[1] 郝传铮[2] 黄丹[1] 顾美珍[1] 

机构地区：[1]南通大学附属医院病理科,江苏南通226001 [2]南通大学附属医院中医科,江苏南通226001

出　　处：《河南肿瘤学杂志》2005年第4期275-276,共2页Henan Journal of Oncology

摘　　要：目的观察鳖甲煎丸和大黄蛰虫丸联合蟾蜍制剂的联合中药治法对大鼠肝癌的抑制作用。方法联合使用鳖甲煎丸、大黄蛰虫丸和蟾蜍制剂作为治疗组,另设正常对照和模型对照各一组。分别观察其对2-乙酰氨基芴诱发大鼠肝癌的死亡率、光镜下病理改变和免疫组化PCNA结果的改变。结果鳖甲煎丸和大黄蛰虫丸联合蟾蜍制剂可以降低大鼠死亡率,减少的癌结节形成,降低PCNA阳性率。结论鳖甲煎丸和大黄蛰虫丸联合蟾蜍制剂治疗对大鼠肝癌的发生有抑制作用,对肝脏某些基因的转录水平有一定的调控作用。Objective To investigate the antitumous effects with united herbsinhibiting hepatocarcinoma rats induced by 2-AAF.Methods To observe the effects of treatment the group with Biejiajianwan, Dahuangzhechongwan and Chanchuzhiji herbs on the rate of death and the group of live pathology and the expression of PCNA of hepatocyle in the rats induced by 2-AAF.Results United herbsinhibiting could reduce the rate of death and the rate of carcinogenesis. The expression of PCNA of hepatocytes was fewer in treatment group than that in positive group. Conclusions The results indicated that united herbsinhibiting could reduce the rate of carcinoma and its mechanism might be related to down-regulate expression of PCNA.affecting cell-cycle process and inhibiting the malignant proliferation and cancerization of hepatocytes.

关 键 词：肝癌 蟾蜍制剂 增殖细胞核抗原 免疫组织化学 

分 类 号：R730.52[医药卫生—肿瘤]