食管癌患者放疗前后血中pi类谷胱甘肽S－转移酶水平的测定  

Plasma Placental Glutathione S-transferase in Esophageal Carcinoma before and after Radiotherapy

作　　者：刘小平[1] 安怀伦[1] 姜缨[1] 

机构地区：[1]西安医科大学第一临床医学院肿瘤科

出　　处：《中国肿瘤临床》1995年第10期706-708,共3页Chinese Journal of Clinical Oncology

摘　　要：用放射免疫法（ＲＩＡ）检测了４０例正常人及６６例食管癌患者放疗前后血浆Ｐｉ类谷胱甘肽Ｓ－转移酶（ＧＳＴ－π）水平。结果显示：食管癌患者放疗前血浆ＧＳＴ－π水平显著高于正常对照（Ｐ＜０．００１），且水平和食管病变长度呈正相关。放疗后血浆ＧＳＴ－π水平显著降低（Ｐ＜０．０１），其水平在完全缓解（ＣＲ）病例与正常对照无明显差异（Ｐ＞０．０５），在部分缓解（ＰＲ）病例仍高于正常对照（Ｐ＜０．００１）。说明食管癌患者血浆ＧＳＴ－π水平与其肿瘤的消长密切相关，有可能成为疗效和判断预后的一个监测指标。The Plasma levels of placental glutathione S-transferase(GST-π)before and after radiotherapy in 66 esophageal carcinoma patients were determinedwith radioimmunoassay(RIA).The data showed that plasma GST-π level in patients was significantly higher than that of healthy controls(P<0. 001).The plasmaGST-π levels correlated with the length of esophagus involved.The Plasma level ofGAT-πwas remarkable reduced at the end of radiotherapy(P<0.01)in good proportion to the immediate radiotherapeutic response.It is suggested that moitoringplasma GST-π level possesses clinical and prognostic significance in patienst withesophageal carcinoma.

关 键 词：Pi类谷胱甘肽S-转移酶 食管肿瘤 放射治疗 

分 类 号：R730.55[医药卫生—肿瘤] R735.105[医药卫生—临床医学]