肝细胞癌与肝硬化患者自发的和丝裂霉素C诱发的SCE的比较观察  

Study on Spontaneous and Mitomycin C Induced SCE in Patients with Hepatoma and Liver Cirrhosis

作　　者：付祝能[1] 赵美芳[1] 陈凯[1] 范顺富[1] 张林坤[1] 曾天定[1] 

机构地区：[1]浙江省金华市中心医院

出　　处：《中国肿瘤临床》1995年第1期21-23,共3页Chinese Journal of Clinical Oncology

摘　　要：通过对３０例正常人、３１例ＨＢＶ感染的肝硬化和２０例ＨＢＶ感染的肝细胞癌（ＨＣＣ）患者进行自发和丝裂霉素Ｃ（ＭＭＣ）诱发的ＳＣＥ同时观察，结果发现，自发ＳＣＥ／细胞的Ｘ±ＳＤ值分别为６．３７±０．５９、１１．６３±１．４６、１４．１５±１．７２，诱发ＳＣＥ分别为８．５２±０．６２、１３．８９±１．１６、１７．１４±２．４３。统计学检验ＨＣＣ组和肝硬化组的自发和诱发ＳＣＥ均极显著高于正常组（ｐ＜０．００１），ＨＣＣ组同时也极显著地高于肝硬化组。Comparative study of spontaneous and mitomycin C induced SCE in peripheral blood lymphocytes in 30 healthy persons,31 hepatocirrhosis and 20 hepatocellular carcinoma(HCC) patients have been carried out.The latter two groups were complicated with the infection of hepatic B virus.The mean value of spontaneous SCE per cell in the above three groups were 6.37±0.59,11.63±1.46 and 14.15±1.72,and that of the induced SCE were SCE 8.52±0.62,13.89±1.16 and 17.14±2.43 respectively.The comparisons showed that both the spontaneous and induced SCE in hepatocirrhosis and HCC groups were significantly higher than those in the healthy group(P<0.001).Meanwhile these values in the HCC group were singnificantly higher than those in the hepatocirrhosis group.

关 键 词：DSCE 淋巴细胞 肝细胞癌 肝硬变 丝裂霉素C 

分 类 号：R735.703[医药卫生—肿瘤] R575.203[医药卫生—临床医学]