IV型胶原纤维及其酶在胃癌浸润转移中的作用  

Role of Type IV Collagen and Type IV Collagenase in the Tissues of Invasion and Mestastasis of Gastric Cancer

作　　者：薛建元[1] 林言箴[1] 尹浩然[1] 王瑞年[1] 朱寿柱 朱正纲[1] 

机构地区：[1]上海第二医科大学瑞金医院外科,海第二医科大学病理教研室

出　　处：《中国肿瘤临床》1995年第4期241-243,共3页Chinese Journal of Clinical Oncology

摘　　要：采用ＩＶ型胶原纤维单抗和ＩＶ型胶原酶多抗检测７６例胃癌。发现ＩＶ型胶原纤维染色所示基底膜明显缺损，在分化较差者及浸润型胃癌中（＞７５％）明显高于分化较好者及膨胀型胃癌（Ｐ＜０．００５）。ＩＶ型胶原酶明显增加在分化较差者，浸润型及有淋巴结转移者（８０％左右）显著高于分化较好者，膨胀型及无淋巴结转移者（Ｐ＜０．０５）。说明分化程度低的胃癌产生更多ＩＶ型胶原酶，严重破坏基底膜，促进浸润和淋巴结转移。其可作为恶性程度指标。Using antibodies of the type IV collagen(cIV) and the type IV collagenase(cIVase)respectively, we examined the distribution of cIV and the state of cIV ase secretion in 76 cases of gastric cancer(GC).As outlined in the cIV staining methd, heavily defective basement membrane(BM)was much more frequently observed in cases with poor histologic differentiation(89. 5%)and in cases presenting the infiltrative growth pattern(76. 6%). Likewise, increased cIVase sectretion was more frequently noticed in cases with poor histologic differentiation(87. 6%),and the cases demonstrating infiltrative growth pattern( 83. 0%)as well as in those with positive lymph nodes(78. 3%).It is concluded that the poorly differentiated cancer cells secrete more cIVase.The cIVase led to break down of BM, with enhances in turn more intensified local infiltration and lymph node metastasis. Examination of cIV and cIVase may behelpful to determine the extent of gastric resection and lymph node clearance.

关 键 词：胃肿瘤 癌 Ⅳ型胶原纤维 浸润 转移 病理 

分 类 号：R735.202[医药卫生—肿瘤]