选择性动脉灌注化疗加放疗联合治疗晚期食管癌的临床研究  

Combination of Selective Arterial Infusion Chemotherapy with Radiotherapy in the Treatment of Advanced Esophageal Carcinoma

作　　者：陆小军[1] 缪锐涵[1] 李晓群[1] 邬建驹 

机构地区：[1]广东省中山市人民医院肿瘤科,广东省中山市人民医院放射科

出　　处：《中国肿瘤临床》1995年第4期262-265,共4页Chinese Journal of Clinical Oncology

摘　　要：１９９０年６月至１９９２年６月选择晚期初诊食管癌６０例，随机分为两组：选择性动脉插管灌注化疗加放疗组和单纯放疗组，前组选用阿霉素６０ｍｇ，５－氟脲嘧啶１ｇ，顺铂４０ｍｇ灌注化疗２疗程后即行放疗。放疗量为ＤＴ５０Ｇｙ／５周。后组放疗量ＤＴ６０－７０Ｇｙ／６～７周。近期疗效判断前组明显优于后组，１年生存率分别为６３．３％和３６．７％，有显著差异。两组副作用无显著差别。From June 1990 to June 1992,60 patients with advanced esophageal carcinoma were randomly divided into two treatment groups: Group A,selective intraterial infusion chemotherapy plus radiotherapy and group B external irradiation alone In group A infusion was given through the tumor supplying artery with ADM 60mg 5-Fu 1g, DDP 40mg for two courses, and, external radiation(DT 50Gy/5 weeks) was started 3 weeks after the conclusion of infusion chemotherapy. In group B,external radiation was given with a total dose of 60-70GY/6-7 weeks. The results showed that the 1-year survival rates of group A and group B were 63. 3% and 36.7% respectively.It seems that the combined therapy resulted in better response rate.The side effects between the two groups showed no significant difference.

关 键 词：食管肿瘤 癌 选择性动脉灌注 化学疗法 放射疗法 

分 类 号：R735.105[医药卫生—肿瘤]