DCC法检测食管鳞癌组织中雌、孕激素胞浆、胞核受体  

Estrogen and Progesterone Receptor in Cytosols and Nuclei of Esophageal Squamous Carcinoma Tissues by DCC Method

作　　者：刘占举[1] 徐志林[1] 刘学勤[1] 

机构地区：[1]河南医科大学第二附属医院内科

出　　处：《中国肿瘤临床》1995年第7期487-490,共4页Chinese Journal of Clinical Oncology

摘　　要：对３０例原发食管鳞癌组织及１６例正常食管组织中雌、孕激素受体在胞浆和胞核（ＥＲｃ、ＥＲｎ、ＰｇＲｃ、ＰｇＲｎ）中分布进行分析，结果显示：正常食管组织中ＥＲｃ、ＥＲｎ、ＰｇＲｃ和ＰｇＲｎ均未检出；癌组织中上述受体含量分别为０～８４．６ｆｍｏｌ／ｍｇ蛋白、０～８７．７ｆｍｏｌ／ｍｇＤＮＡ、０～６８．０ｆｍｏｌ／ｍｇ蛋白和０～６９．４ｆｍｏｌ／ｍｇＤＮＡ，阳性率分别为３６．７％、３３．３％、３０％和３０％，受体含量及阳性率均明显高于正常食管组织（Ｐ＜０．０５）。上述受体阳性率随癌组织学分级增加而明显下降，且女性高于男性（Ｐ＜０．０５）。The estrogen and progesterone receptors in cytosols(ERc,PgRc)and nuclei(ERn,PgRn)were measured in 30 specimens ofprimary esophageal squamous carcinoma and 16 normal esophageal tissues.The results demonstrated thatcontents of ERc,ERn,PgRc and PgRn in tumor tissues ranged from 0-84.6 fmol/mg protein,0-87.7 fmol/mg DNA,0-68.0 fmol/mg protein and 0-69.4 fmol/mgDNA respectively,and were absent in the normal esophageal tissues.The positive rates of the hormone receptors mentioned above were 36.7%,33.3%,30% and 30% respectively in the tumor tissues.Esophageal Squamous carcinoma had a significantly higher receptor concentrations and positive rates than the normal tissues(P<0.05).The well differentiated cancers had higher positive rates than the poor differentiated ones and the females had higher positive rates than the males(P<0.05).

关 键 词：食管肿瘤 雌激素 受体 孕激素 DCC法 

分 类 号：R735.104[医药卫生—肿瘤] R730.43[医药卫生—临床医学]