胃癌病人骨髓微小转移灶的定量检测及临床意义  

Detection and Count of Micrometastatic Focus in Bone Marrow with Immunohistochemistry and Its Clinical Significance in Patients with Stomach Cancer

作　　者：赵增顺[1] 刘福坤[1] 谭海东[1] 臧静 王少文[1] 刘思文[1] 

机构地区：[1]白求恩国际和平医院普外科,中国人民解放军南京军区总医院普外中心

出　　处：《中国肿瘤临床》1995年第8期533-536,共4页Chinese Journal of Clinical Oncology

摘　　要：自１９９３年２月开始，采用抗上皮细胞单克隆抗体（抗ＥＭＡ单抗）为探针，利用免疫组化染色技术对胃癌患者进行骨髓内微小转移灶的临床研究。经对６５例胃癌患者的检测，阳性细胞检出率为５８．４％，对阳性结果患者进行了综合治疗对照观察，治疗前、后阳性结果有显著性变化，治疗前阳性细胞平均数为９．４５，治疗后为２．１８，经统计学分析治疗前、后阳性细胞数发现率有显著性变化（ｔ＝２．７７Ｐ＜０．００５）。分析结果表明，此项技术不但对胃癌病人有无血道转移提供客观依据，而且对临床的综合治疗也有重要的指导意义。Since February 1992, the detection of epithelial membrane antigen(EMA), for micrometastatic focus in bone marrow was carried out in 65 patients with primary gastric cancer and a positive rate was 59.46% was obtained. Due treatment was given to positive patients. It was found that there was apparent difference between the positive rates of pre- and post-treatment(P<0.005). The results suggested that this technique was helpful in the diagnosis of micrometastases in bone marrow and that it bears significant importance in the planning of comprehensive treatment.

关 键 词：上皮细胞 抗原 胃肿瘤 综合疗法 骨髓转移 

分 类 号：R735.206[医药卫生—肿瘤] R733.304[医药卫生—临床医学]