膀胱癌细胞p53基因蛋白表达的临床意义  

Expression of p53 Protein in Transitional Cell Carcinoma of the Bladder and It's Clinical Significance

作　　者：李伯全[1] 洪声涛 高兴茂 左连富[1] 

机构地区：[1]解放军第254医院泌尿外科,河北医学院第四医院泌尿外科,河北省肿瘤研究所

出　　处：《中国肿瘤临床》1995年第9期617-619,637,共4页Chinese Journal of Clinical Oncology

摘　　要：采用流式细胞术和细胞免疫荧光染色技术，对４２例膀胱癌ｐ５３蛋白表达进行了分析，结合随访结果进行回顾性研究。结果表明，ｐ５３表达与肿瘤分级密切相关：Ⅰ级２２．２％，Ⅱ级５７．１％，Ⅲ级８３．３％。结合ｐ５３表达和ＤＮＡ倍体对预后作了综合分析，显示ｐ５３阳性异倍体肿瘤患者的生存率最低，ｐ５３阳性肿瘤患者的生存率次之，而二倍体肿瘤患者的生存率最高。在复发的膀胱肿瘤中，ｐ５３阳性表达（８１．３％）显著高于ｐ５３阴性表达（１８．７％）。提示测定膀胱肿瘤ｐ５３表达，对预后可作出客观预测。p 53 expression and DNA ploidy were examined in 42 transitional cell carcinomas of the bladder with flow cytometry and cyto-immunofluorescence staining technique using monoclonal antibody PAb 1801. The results were retrospectively analysed relative to the outcome of patients on follow up. It was shown that p53 was only expressed on tumor cell. It was also seen that the percentage of p53 positivity increased apparently in parallel to the increase of pathological grading.The p53 positive rate was higher in recurrent tumors than that in nonrecurrent tumors.The results suggest that p53 overexpression would be an objective indicator of poor prognosis.

关 键 词：预后 流式细胞术 膀胱肿瘤 P53基因 基因表达 

分 类 号：R737.140.2[医药卫生—肿瘤] R737.140.7[医药卫生—临床医学]