甲胎蛋白在诊断丙型肝炎相关肝细胞癌临床价值的探讨  

Clinical Values of AFP in the Diagnosis of Hepatocellular Carcinoma

作　　者：柯伟民[1] 泉哲 兴隆 进士义刚 王飞[1] 

机构地区：[1]中山医科大学传染病学教研室,日本兵库县,日本兵库县立西宫病院内科,日本兵库县立西宫病院病理室

出　　处：《中国肿瘤临床》1995年第10期694-695,共2页Chinese Journal of Clinical Oncology

摘　　要：比较８０例不同病理类型的丙型肝炎（ＨＣ）和３０例丙型肝炎相关肝细胞癌（ＨＣＲＨＣＣ）的甲胎蛋白（ＡＦＰ）异常率。结果提示，ＡＦＰ仍是协助ＨＣＲＨＣＣ诊断的一项较好的参考指标。不过，异常率仅是５６．７％（１７／３０），ＡＦＰ水平＞４００μｇ／Ｌ和１０００μｇ／Ｌ的ＨＣＲＨＣＣ病人也仅是２６．７％（８／３０）和１３．３％（４／３０）。在ＡＦＰ异常的ＨＣ病人怀疑ＨＣＲＨＣＣ时，应借助肝脏影像学。在ＡＦＰ正常的ＨＣ病人怀疑ＨＣＲＨＣＣ时，应检查其它肝癌标志和肝脏影像学。The abnormal rates ofalpha-fetoprotein(AFP) were comparedbetween the 80 cases of hepatitis C(HC) of different pathological types and 30 casesof hepatitis C-related hepatocellular carcinomas(HCRHCC).The results suggestthat the AFP still is a good referential index in the diagnosis of HCRHCC.Nevertheless,the abnormal rate was only 56.7%(17/30),andthe patients with HCRHCCwhose AFP levels were more than 400μg/L and 1000μg/L accounted for only26.7%(8/30)and 13.3%(4/30).When HCRHCC is suspected in patients who suffer from HC with abnormal AFP, the liver should underdo imaging diagnostic studies. When HCRHCC is suspected in the patients who suffer from HC with normalAFP, the other markers of HCC should be exomined as well as imaging tests.

关 键 词：甲胎蛋白 丙型肝炎 肝细胞癌 肝肿瘤 诊断 

分 类 号：R512.630.4[医药卫生—内科学] R735.704[医药卫生—临床医学]