放射性核素生物导向技术对乳腺癌腋窝淋巴结转移的临床应用价值  

Role of Radionuclide Biological Targeting Technique on the Detection of Axillary Lymph Node Metastases in Breast Cancer

作　　者：冯珏[1] 高友恭[1] 冯亚丽[1] 吴建华 

机构地区：[1]河北医学院附属第二医院

出　　处：《中国肿瘤临床》1995年第11期798-800,共3页Chinese Journal of Clinical Oncology

基　　金：河北省科委基金

摘　　要：应用￣（１３１）Ⅰ标记的单克隆抗体Ｃ＿（５０）对１１例乳腺癌患者及２例正常人进行放射性核素生物导向诊断，结果８例呈阳性显像，其中７例术后经病理证实，另１例术后切下的７个淋巴结常规病理检查未找到癌细胞，免疫组化证实淋巴窦腔内存在癌胚抗原及抗原－抗体免疫复合物。３例显像阴性者术后病理检查未找到癌细胞。２例正常对照者（４侧腋窝）均阴性显像。木研究证明：该方法诊断乳腺癌腋窝淋巴结转移灶可以准确定性、定位，对指导临床手术有一定价值。Eleven patients with breast cancer and 2 normal individuals were studied by radionuclide biological targeting technique with 131Ⅰ labelled monoclonal antibody C50. The imaging was recognized as Positive in 8 Patients and negative in 3 patients.In 7 of the eight positive patients the lymph nodes were proven pathologically to harbor metastatic foci and the eighth was found to contain CEA-antigen and antigen-antibody immunocomplexes in the lymphoid sinus by immunohistochemistry. No cancer cell was found histologically in the axillary lymph nodes of 3negative imaging gatients. As to the 2 normal controls imaging was negative.The results of this study not only demonstrated that the radionuclide biological targeting technique was useful in the diagnosis and localization of axillary lymph node metastases from breast cancer,but also indicated great clinical significance in surgery.

关 键 词：乳腺癌 腋窝淋巴结转移 诊断 放射性核素 碘131 

分 类 号：R730.44[医药卫生—肿瘤] R737.904[医药卫生—临床医学]