肾恶性横纹肌样瘤15例临床病理及免疫组织化学分析  

Malignant rhabdoid tumor of kidney:a clinicopathologic and immunohistochemical study of 15 patients

作　　者：刘予[1] 李佩娟[1] 刘淑荣[1] 黄澄如[1] 孙宁[1] 

机构地区：[1]北京儿童医院病理科,北京儿童医院外科

出　　处：《中华病理学杂志》1995年第2期72-74,共3页Chinese Journal of Pathology

摘　　要：报道１５例肾恶性横纹肌样瘤（ＭＲＴＫ）的临床病理及免疫组化特点。男女之比为２．８：１。年龄４个月至４岁７个月，平均１岁零６个月。随访１０例，８例均于术后半年内死１０亡，２例健在。典型组织学改变为细胞弥漫排列，多边形，胞浆丰富嗜酸性，核仁突出。部分细胞胞浆内有嗜酸性包涵体，部分病例可见上皮样排列，间质硬化及梭形细胞成分。免疫组化显示１５例Ｖｉｍｅｎｔｉｎ（＋），１２例ＥＭＡ（＋），８例Ｃｙｔｏｋｅｒａｔｉｎ（＋）。结果提示，本瘤是一种好发于婴幼儿、预后差、多表现型的恶性肾肿瘤。可能来源于某种具有双向分化能力的多潜能细胞。he clinical and pathological feat ures of 15 infants with malignant rhabdoid tumors of kidney are presented.These tumors were identified among 391 primary renal neoplasms in this hospital.The male/female ratio was 2.8:1.0, mean age at diagnosis was 18 months with a range from 4 to 55 months. Of the 10 patients with follow-up records, 8 have died,2 were alive and free of disease 15 and 55 months after the diagnosis respectively.A wide histologic spectrum was encountered.All tumors exhibited clas-sical morphology in at least some areas,characterized by solid proliferation of monotonous tumor cells with vesicular nuclei and prominent nucleoli,abundant cytoplasm and intracytoplasmic inclusions. Im-munohistochemical studies were performed in all 15 cases. Vimentin was positive in all tumors,ENA in12,cytokeratin in 8,desmin in 2 and myoglobin in one. All cases were negative for presence of lysozyme,NSE and neurofilament;Our results show that this tumor is a distinctive and highly malig-nant neoplasm of the infant kidney with considerable morphological and immunohistochemical diverse phenotypes.

关 键 词：肾肿瘤 免疫组织化学 临床病理 

分 类 号：R737.110.2[医药卫生—肿瘤]