造釉细胞瘤中抗凋零基因bc1－2表达产物的分布及意义  

Detection of the apoptosis-suppressing oncoprotein bc1-2 in ameloblastomas

作　　者：高玉好[1] 杨连甲[1] 朱萧玲[1] 

机构地区：[1]西安第四军医大学口腔医学院病理学教研室

出　　处：《中华病理学杂志》1995年第2期78-79,共2页Chinese Journal of Pathology

摘　　要：抗凋零基因ｂｃ１－２的表达产物可抑制细胞调零过程，从而导致肿瘤发生。我们利用免疫组化方法观察了４０例造釉细胞瘤中ｂｃ１－２基因产物的表达与分布。ｂｃ１－２基因产物主要位于正常牙胚的造釉上皮、缩余釉上皮和造牙本质细胞中，正常口腔粘膜上皮和牙源性囊肿上皮的基底层细胞可见ｂｃ１－２基因产物阳性。４０例造釉细胞瘤，ｂｃ１－２阳性病例达９０％。本文结果提示，ｂｃ１－２在牙源性上皮中的表达与细胞的分化程度有关，ｂｃ１－２的过量表达可能参与了造釉细胞瘤的形态发生过程。he eproduct of apoptosis-suppressing oncoprotein bc1-2 can block apoptosis and result in the development of tumors.In this study,the expression of bc1-2 was observed in 40 cases of ameloblas-tomas by immunohistochemical staining. The results showed that the epithelium and reduced enamel ep-ithelium of the enamel organ,the odontoblasts,basal cells of odontogenic cysts,normal oral epithelium and 90%(36/40) of amelobiastomas were positive for bc1-2,indlcating that the expression of bc1-2 in odontogenic epithelium may be related to the degree of differentiation and proliferation of cells,the over-expression of bc1-2 may be associated with the developrnent of ameloblastoma.

关 键 词：釉质母细胞瘤 形态发生 基因表达 口腔肿瘤 

分 类 号：R730.261[医药卫生—肿瘤] R739.8[医药卫生—临床医学]