nm23基因产物／NDPK在大肠癌中的表达及其临床意义  

nm23 gene product/NDPK expression and its clinical significance in human colorectal carcinoma

作　　者：王川[1] 张祥福[1] 杨发端[1] 卢辉山[1] 殷凤峙[1] 

机构地区：[1]福建医学院附属协和医院肿瘤科,福建医学院附属协和医院病理科,福建医学院附属协和医院普外科

出　　处：《中华病理学杂志》1995年第6期356-358,共3页Chinese Journal of Pathology

摘　　要：应用免疫组化Ｓ－Ｐ方法，研究１０３例大肠癌手术标本中ｎｍ２３基因产物／ＮＤＰＫ的表达及其意义。结果显示：大肠癌原发灶中ＮＤＰＫ表达阳性率７６．７％；其中，无区域淋巴结转移者阳性率为９０．５％，伴区域淋巴结转移者阳性率６７．２％，差异具有显著性意义（Ｐ＜０．０５）；随着大肠癌浸润肠壁深度和Ｄｕｋｅｓ＇分期的进展，原发灶中ｎｍ２３／ＮＤＰＫ表达阳性率逐渐下降，统计学均具有显著性意义（分别Ｐ＜０．０１、Ｐ＜０．０５）；ｎｍ２３／ＮＤＰＫ表达阳性者术后３、５年生存率分别为６５．８％和５４．４％，明显高于ＮＤＰＫ阴性患者术后３年和５年生存率（３７．５％和２０．８％），统计学具有显著性意义（分别Ｐ＜０．０５、Ｐ＜０．００５）。我们认为：ｎｍ２３基因在大肠癌的浸润和淋巴结转移过程中发挥负性调控作用。测定大肠癌组织中ｎｍ２３基因产物／ＮＤＰＫ的表达状况，有助于对大肠癌生物学行为的进一步了解及对患者预后的判断。he expression of nm23 gene product/NDPK was examined immnunohistochemically in resected hu-man colorectal carcinomas using anti-NDPK polyclonal antibody. Of the 103 carcinomas tested,76.7%(79 cases)showed positive staining of nm23/NDPK in the primary lesions.In patients without regional lymph node metastasis,the positive staining rate(90.5%,38/42) was significantly higher than that in those with nodal involvement(67.2%,41/61).Inverse relationships were found between nm23/NDPK expression and tumor invasion or the progression of Dukes'staging. Expression of NDPK was positively associated with longer post-operative survival and the relationship was significant.Therefore,our data indicated that nm23 gene plays an important role in lymph node metastasis and invasion in colorectal car-cinomas. The expression of nm23 gene product/NDPK may be a useful tool for prognosis of human col-orectal carcinomas

关 键 词：基因表达 大肠肿瘤 NM23基因 二磷酸核苷激酶 

分 类 号：R735.340.2[医药卫生—肿瘤] R730.2[医药卫生—临床医学]