多氯联苯的羟基化代谢产物及其内分泌干扰机制  

Hydroxylated Metabolites of Polychlorinated Biphenyls and Their Endocrine Disrupting Mechanism

作　　者：杨方星[1] 徐盈[1] 

机构地区：[1]中国科学院水生生物研究所淡水生态和生物技术国家重点实验室

出　　处：《化学进展》2005年第4期740-748,共9页Progress in Chemistry

基　　金：国家重点基础研究专项经费项目(No.2003CB415005);中国科学院方向性创新项目(KZCX2-414;KZCX3-SW-431)资助

摘　　要：羟基多氯联苯是典型持久性有机污染物(POPs)———多氯联苯在生物体内的主要活性代谢产物,已在许多野生动物和人体内被检出。由于其化学结构与天然雌激素、甲状腺激素十分类似,因此羟基多氯联苯的内分泌干扰效应近年来已开始受到国际上的高度关注。本文对多氯联苯的代谢途径、羟基多氯联苯在生物体内的浓度水平、内分泌干扰及其多种毒性作用机制进行了综述。有关对多氯联苯的活性代谢产物———羟基多氯联苯的深入研究,将有助于进一步揭示多氯联苯的毒性机制,为我国早日建立有效的POPs污染危害评价与早期预警系统提供科学依据。Hydroxylated polychlorinated biphenyls (OH-PCBs a group of main active metabolites of polychlorinated biphenyl (PCBs) which are typical persistent organic pollutants (Pops) I have been identified in wild animals and human. The endocrine disruption of OH-PCBs has been drawn great attention due to the similarity of their chemical structures to the natural estrogens and thyroid hormones. The metabolic pathways of PCBs, the levels of OHPCBs in organism, the endocrine disruption and other adverse effects of OH-PCBs are reviewed. The further investigation of OH-PCBs will not only reveal the toxicological mechanism of PCBs, but also can lay scientific basis for setting up the risk assessment of POPs contamination and early-warning system in China.

关 键 词：多氯联苯 羟基多氯联苯 内分泌干扰 

分 类 号：X17[环境科学与工程—环境科学] X503