釉基质蛋白骨诱导作用的实验探讨  

An in vivo study on osteoinductive property of enamel matrix proteins

作　　者：杜岩[1] 吴织芬[1] 万玲[1] 董广英[1] 

机构地区：[1]西安第四军医大学口腔医学院牙周病科,710032

出　　处：《实用口腔医学杂志》2005年第4期480-482,共3页Journal of Practical Stomatology

摘　　要：目的:观察提取的猪釉基质蛋白是否具有骨诱导作用。方法:采用大鼠腓肠肌肌袋内成骨模型观察釉基质蛋白是否具有骨诱导作用。实验分为2组,采用自体对照,实验组埋入以藻酸丙二醇酯为载体的釉基质蛋白,对照组埋入藻酸丙二醇酯。1个月后处死动物。结果:经大体及组织学观察,大鼠腓肠肌肌袋埋植处瘢痕愈合,未见有骨样或软骨样组织形成。结论:提取的猪釉基质蛋白未具有骨诱导作用。Objective:To investigate whether enamel matrix proteins (EMPs) has osteoinductive property. Methods: EMPs and propylene glycol alginate (PGA) in the size of 2 mm3 were placed into calf muscle of 8 SD rats on experiment side. PGA was placed on control side. The rats were sacrificed four weeks after operation. The calf samples were examined by histological observation.Result:Bone-like and/or cartilage-like tissues was not observed in all the operated calf muscles. Conclusion:EMPs are not osteoinductive.

关 键 词：大鼠 牙釉质蛋白质类 骨诱导作用 

分 类 号：R780.2[医药卫生—口腔医学]