高强度聚焦超声治疗肿瘤疗效的临床观察  

Clinical study of the treatment for solid tumors by high intensity focused ultrasound

作　　者：王琳[1] 秦叔逵[1] 耿兰溪[2] 邵志坚[1] 范晓燕[1] 

机构地区：[1]南京八一医院全军肿瘤中心内科,江苏南京210002 [2]南京八一医院特诊科,江苏南京210002

出　　处：《肿瘤防治杂志》2005年第11期864-866,共3页China Journal of Cancer Prevention and Treatment

摘　　要：为了探讨高强度聚焦超声(highintensityfocusedultrasound,HIFU)治疗肿瘤的初步疗效和安全性。对30例肿瘤患者进行HIFU治疗,观察患者治疗前后生命体征、主要脏器功能、影像学检查、病理组织学检查和并发症的情况。结果显示,所有患者治疗中、治疗后生命体征稳定,对靶区外邻近器官、组织无明显影响。30例患者治疗前有疼痛者18例,治疗后疼痛缓解显效者4例,有效者8例,有效率65.6%(12/18)。尿频尿急4例,治疗后有效2例。肛门坠胀8例,治疗后有效3例。大便困难2例,有效者1例。所有患者B超下均有不同程度的回声增强,但肿瘤大小无明显变化。3例患者HIFU治疗后手术切除靶区内组织呈大块凝固性坏死。HIFU治疗肿瘤是一种安全有效的方法,值得进一步临床研究。The objective of this study was to investigate the efficacy and safety of high intensity focused ultrasound (HIFU) in the treatment of solid tumor. Thirty patients were treated by HIFU. Before and after HIFU treatment, the vital organ signs, funcation of important organs, imaging, histopathology and complications were evaluated. During and after HIFU procedure, the vital signs remained stable. There was no adjacent tissue damage outside targeted areas. Eighteen cases ammg all the cases had pain before the treatment, and after the treatment of HIFU, the pain was significantly relieved in 4 cases and relieved in 8 cases, and the total effective rate was 65.6%(12/18). Four cases had sychnuria and urgencultrasound, and after the treatment of HIFU, there were 2 cases responsed. Anus bearing-down was in 8 cases, and 3 cases were effective. Dyschesia was in 2 cases, and 1 case was effective. Echo of carcinoma tissue was enhanced in all the patients, and the tumor size had no significant change. The coagulative necrosis of tissue in the targeted areas was seen in 3 cases. In conclusion, the treatment of tumor with HIFU is safe and effective, and it is worth of further clinical trial.

关 键 词：超声检查 多普勒 彩色 超声疗法 超声检查 治疗结果 

分 类 号：R730.5[医药卫生—肿瘤]