艾迪注射液改善消化道肿瘤化疗患者生存质量的临床观察  

Clinical study on efficacy of AiDi injection combined with chemotherapy in the treatment of advanced alimentary canal carcinoma

作　　者：孙毅[1] 盛桂凤[1] 

机构地区：[1]常州肿瘤医院肿瘤内科,江苏常州213000

出　　处：《肿瘤防治杂志》2005年第12期945-946,共2页China Journal of Cancer Prevention and Treatment

摘　　要：为观察艾迪注射液改善消化道肿瘤化疗患者生存质量的情况,对47例消化系恶性肿瘤患者用信封法随机分为两组,治疗组22例和对照组25例。治疗组在化疗的同时加用艾迪注射液,对照组单纯采用化疗。毒性反应评价按WHO抗癌药急性和亚急性毒性表现与分级标准评价。根据KPS评分和体质量增加或减少的情况进行生活质量评估。观察两组治疗前后生存质量改变及毒副反应。治疗组生活质量评分提高者13例,稳定者5例,下降者3例;对照组提高者7例,稳定者5例,下降者13例。治疗组提高率和下降率分别为59%和13.6%,而对照组分别为28%和52%,差异均有统计学意义,P<0.05。治疗组白细胞下降发生率为36.3%(8/22)对照组为36%(9/25),两组比较差异无统计学意义,P>0.05,治疗组胃肠道反应(恶心、呕吐)发生率为40.9%(9/22),对照组为64%(16/25),两组比较差异有统计学意义,P<0.05。其他不良反应两组均较轻。初步研究结果提示,艾迪注射液可改善消化道肿瘤化疗患者生存质量,降低化疗毒副反应。To evaluate the efficacy of AiDi injection on improving patients' quality of life (QOL) who suffered from advanced alimentary canal carcinoma and were treated with chemotherapy. forty seven cases of advanced alimentary canal carcinoma were divided into two groups, trail group(22 cases) and control group(25 cases). In the trail group ,chemotherapy combined with AiDi injection were given intravenously while in the control group ,only given chemotherapy. The improvement of QOL in the trail group was higher than that in the control group (P<0.05) and the adverse reactions were lower than those in the control group (P<0.05) Conclusion AiDi injection could decrease the adverse reactions of chemotherapy and improve the quality of life in patients with advanced alimentary canal carcinoma.

关 键 词：艾迪注射液 消化道肿瘤 生存质量 治疗 

分 类 号：R735[医药卫生—肿瘤]