腹腔内联合灌注化疗治疗恶性腹膜间皮瘤的临床研究  

Intraperitoneal combination chemotherapy for patients with malignant peritoneal mesothelioma

作　　者：张树荣[1] 张彦[2] 陈卫华[1] 

机构地区：[1]成都军区昆明总医院消化内科,云南昆明650032 [2]成都军区昆明总医院质量管理科,云南昆明650032

出　　处：《肿瘤防治杂志》2005年第14期1098-1099,共2页China Journal of Cancer Prevention and Treatment

摘　　要：目的探讨腹腔内联合化疗治疗恶性腹膜间皮瘤(malignant peritoneal mes-othelioma,MPM)的疗效。方法采用多柔比星30mg/m2+顺铂25mg/m2+丝裂霉素4～6mg联合化疗方案对19例MPM患者进行腹腔内注射,每周1次,每例共注射3～4次,分析腹水变化情况。结果近期疗效CR10例(52.6%),PR6例(31.6%),NC3例(15.8%),有效率(CR+PR)为84.2%,显著高于对照组(41.7%),χ2=6.09187,P<0.025。不良反应轻微。结论腹腔内联合化疗治疗MPM近期疗效好,不良反应少,是MPM的有效治疗方法之一。OBJECTIVE:To explore the curative effect of malignant peritoneal mesothelioma (MPM) with intraperitoneal combination chemotherapy. METHODS: Nineteen patients with MPM were treated with a combination chemotherapy protocol consisting of adriamycin, cisplatin and mitomycin through injection of peritoneal cavity once a week. Every patient was treated 3-4 times.RESULTS: The short-term therapeutic efficacy was CR 52.6% (10/19),PR 31.6% (6/19),NC 15.8% (3/19), respectively. The response rate in the chemotherapy group (84.2%) was significant higher than that in the control group (41.7%), χ2=6.091 87,P<0.025.CONCLUSIONS: The short-term therapeutic efficacy is significant in the treatment of MPM with intraperitoneal combination chemotherapy. It may be one of the effective therapeutic methods for MPM.

关 键 词：腹腔积液/药物疗法 药物疗法 联合 注射 腹腔 

分 类 号：R735.5[医药卫生—肿瘤]