卡铂用于腹腔化疗的药代动力学测定  

Phamacokinetics study of intraperitoneal carboplatin in gynecologic carcinoma

作　　者：涂持坤[1] 孟玉春 杨晓东[1] 王卫[1] 杨桂芝[1] 徐虹[1] 孙雪丽[1] 

机构地区：[1]天津第二医学院附属第一中心医院妇科,天津市医药科学研究所

出　　处：《中华妇产科杂志》1995年第4期212-214,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：选择１９９１年１２月至１９９２年１２月本院妇科恶性肿瘤病人接受卡铂化疗者２０例，肝肾功能正常，无吸烟，其中１５例经腹腔化疗，５例经静脉化疗。应用石墨炉原子光谱吸收法，监测两种不同途径给药后血清总铂浓度随时间变化的各变量值，计算各药代动力学参数。结果：静脉给药者血清最大平均总铂浓度是经腹腔给药者的８倍以上，药物体内分布容积分别为０．３５±０．１１Ｌ和０．８７±０．３７Ｌ（Ｐ＜０．０５）；总清除率分别为１．８８±０．５３ｍｌ／ｍｉｎ和１．１２±０．５８ｍｌ／ｍｉｎ（Ｐ＜０．０５）；清除半衰期分别为１０．８２±４．９５小时和５４．０４±１０．７５小时（Ｐ＜０．０５）。提示：卡铂经腹腔给药后，药物在体内分布较广，血清中浓度低，从体内消除缓慢，有可能提高其抗肿瘤效应，降低其髓内毒性。Twenty patients with surgically and pathologically confirmed gynecologic cancer from December,1991 to December,l992 were treated by intraperitoneal (IP)chemotherapy with carboplatin in 15 and by intravenous(IV)chemotherapy with carboplatin in 5, patients had normal hepatic and renal function test and were nonsmoker。Using Grathite atomic absorption spectrum method, total mean maximal plas-mic carboplatin concentration in the cases by intravenous infusiOn was 8 times greater than those by in-traperitoneal infusion。The half-life of plasmic elimination in the cases treated by IV infusion and by IP infusion were respectively l0.82±4.95 hours and 54.04±10.75 hours(P<0.05).But total carbopltin plasmic clearance in the cases were l.88±0.53ml/min and l.12±0.58ml/min,respectivelly(P<0.05).Pharmacokinetic profiles suggest a possible therapeutic advantage by giving the drug intraperi-toneally for the treatment of tumour nodules situated in the peritoneum.This research also suggest the method has the possibility in increasing antitumn effect and decreesing bone marrow in toxication be cause of the wide distribution,low plasmic concertration and slow clearance of drugs.

关 键 词：药代动力学 女性生殖器肿瘤 卡铂 药物疗法 

分 类 号：R737.305[医药卫生—肿瘤] R979.1[医药卫生—临床医学]